Paajanen H, Satokari K, Uotila P, Kormano M
Eur J Radiol. 1986 May;6(2):132-5.
In view of the possible role of prostaglandins (PG) and thromboxane (TX) in the disturbances of renal function and blood flow after the injection of diatrizoate into the renal artery, we have determined the levels of PGE2, 6-keto-PGF1 alpha (a stable metabolite of prostacyclin) and TXB2 in the renal venous blood before, during and after renal arteriography in 12 patients. Radioimmunologically assayed PGE2 was the most abundant prostaglandin in renal venous blood. Lower basal levels of PGs were associated with renal adenocarcinomas or other tumours than non-tumour kidneys. The concentrations of 6-keto-PGF1 alpha and PGF2 alpha rapidly increased after diatrizoate injection and returned to the basal levels within 5 minutes. Slower elevation was noticed in the PGF2 level of 5 tumour kidneys. Renal plasma concentration of TXB2 remained unchanged throughout the study. The rapid elevation of renal venous prostacyclin and PGF2 alpha concentration after the contrast injection may reflect the enhanced intrarenal prostaglandin synthesis or may be secondary to hemodynamic changes in the kidney caused by hypertonic diatrizoate.
鉴于前列腺素（PG）和血栓素（TX）在向肾动脉注射泛影葡胺后肾功能和血流紊乱中可能起的作用，我们测定了12例患者肾动脉造影术前、术中和术后肾静脉血中PGE2、6-酮-PGF1α（前列环素的稳定代谢产物）和TXB2的水平。放射免疫法测定的PGE2是肾静脉血中含量最丰富的前列腺素。与非肿瘤肾脏相比，PG的基础水平较低与肾腺癌或其他肿瘤有关。注射泛影葡胺后，6-酮-PGF1α和PGF2α的浓度迅速升高，并在5分钟内恢复到基础水平。5例肿瘤肾脏的PGF2水平升高较慢。在整个研究过程中，肾血浆TXB2浓度保持不变。注射造影剂后肾静脉前列环素和PGF2α浓度的迅速升高可能反映了肾内前列腺素合成的增强，也可能是高渗泛影葡胺引起的肾脏血流动力学变化的继发结果。
