Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Department of Ophthalmology, Uzsoki Hospital, Budapest, Hungary.
PLoS One. 2021 Oct 1;16(10):e0258126. doi: 10.1371/journal.pone.0258126. eCollection 2021.
The study aimed at a quantitative evaluation of macular vasculature after primary repair of rhegmatogenous retinal detachment (RRD) in correlation with the elapsed postoperative time. Optical coherence tomography angiography (OCT-A) was performed in 66 eyes of 33 patients in a retrospective case-control study: superficial and deep retinal vessel density (VD) of the whole image, fovea, parafovea, non-flow area, and foveal avascular zone (FAZ) were measured. Data of eyes with RRD were compared to the healthy fellow eyes in 3 groups according to the elapsed time after surgery: RD1: 6-12 months (n = 10), RD2: 1-2 years (n = 10), and RD3: 2-10 years (n = 13). In RD1 VD was significantly lower in the superficial parafoveal, deep parafoveal, and deep whole area compared to the fellow eyes. In RD3 VD was significantly lower in the superficial fovea, parafovea, whole image, and deep fovea, the non-flow area was significantly enlarged. OCT-A demonstrated a significant reduction in the superficial and deep regions of the macular vasculature after the repair of RRD. The deep area is more affected in the early postoperative period and the superficial region and the extent of the non-flow area are more involved after a longer postoperative time.
本研究旨在定量评估孔源性视网膜脱离（RRD）初次修复后与术后时间相关的黄斑血管变化。在一项回顾性病例对照研究中，对 33 名患者的 66 只眼进行了光学相干断层扫描血管造影（OCT-A）检查：测量了整个图像、黄斑中心凹、旁中心凹、无血流区和中心凹无血管区（FAZ）的浅层和深层视网膜血管密度（VD）。将手术 6-12 个月（n=10）、1-2 年（n=10）和 2-10 年（n=13）的三组 RRD 眼的资料与健眼进行比较。与健眼相比，RD1 浅层旁中心凹、深层旁中心凹和深层整个区域的 VD 明显降低。在 RD3 中，浅层黄斑中心凹、旁中心凹、整个图像和深层黄斑中心凹、无血流区的 VD 明显降低，无血流区明显扩大。OCT-A 显示 RRD 修复后黄斑血管浅层和深层区域明显减少。在术后早期，深层区域受影响更大，而在较长的术后时间内，浅层区域和无血流区域的范围更大。
