Department of Ophthalmology, Jeju National University School of Medicine, Jeju National University Hospital, Jeju, Korea.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Sci Rep. 2020 Feb 13;10(1):2555. doi: 10.1038/s41598-020-59504-3.
Silicone oil (SO) is widely used as a long-term intravitreal tamponading agent for rhegmatogenous retinal detachment (RRD) repair. This study investigated the structural changes of the foveal microvasculature using optical coherence tomography angiography (OCTA) in patients with RRD treated with vitrectomy and SO tamponade. Thirty-eight patients with unilateral RRD who were treated with vitrectomy and SO tamponade and were followed up for ≥3 months after SO removal were included. En face OCTA images were obtained and foveal avascular zone (FAZ) area and vascular density (VD) were compared between study eyes and unaffected contralateral eyes. The FAZ area in deep capillary plexus (DCP) was larger (P < 0.001) and the VD in DCP was lower (P = 0.022) in the study eyes than in the fellow eyes. The duration of SO tamponade was significantly correlated with the enlargement of FAZ area (P = 0.034) and reduction of VD in DCP (P = 0.015). These changes could reflect vascular insufficiency in eyes with SO tamponade and may represent a potential explanation for the pathogenesis of retinal thinning and unexplained visual loss.
硅油（SO）被广泛用作裂孔源性视网膜脱离（RRD）修复的长期眼内填塞剂。本研究通过光相干断层扫描血管造影（OCTA）观察接受玻璃体切割术联合 SO 填充治疗的 RRD 患者的黄斑区微血管结构变化。纳入 38 例接受玻璃体切割术联合 SO 填充治疗并在 SO 取出后随访≥3 个月的单侧 RRD 患者。获取 OCTA 图像，比较研究眼和未受影响的对侧眼的黄斑中心无血管区（FAZ）面积和血管密度（VD）。研究眼的深层毛细血管丛（DCP）FAZ 面积较大（P<0.001），DCP 的 VD 较低（P=0.022）。SO 填塞时间与 FAZ 面积增大（P=0.034）和 DCP 中 VD 降低（P=0.015）显著相关。这些变化可能反映了 SO 填塞眼的血管功能不全，可能代表了视网膜变薄和不明原因视力丧失的发病机制的潜在解释。
