小胶质细胞的团队精神：共同承担清除毒性聚集体的负担。

Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates.

机构信息

Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Cell. 2021 Sep 30;184(20):5082-5084. doi: 10.1016/j.cell.2021.08.033.

DOI:10.1016/j.cell.2021.08.033

Abstract

Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.

摘要

小胶质细胞在神经退行性疾病的防御中发挥着关键作用。在本期《细胞》杂志中，Scheiblich 等人关注的是吞噬α-突触核蛋白毒性聚集物的小胶质细胞，他们发现富含α-突触核蛋白的小胶质细胞通过与未受影响的小胶质细胞的纳米管连接，将聚集物交换为健康的线粒体。这种通讯使它们能够共享聚集物处理的方法，同时保持小胶质细胞群体的健康。