分享即关爱：在小胶质细胞网络中分布蛋白聚集体的益处。

Sharing is caring: The benefits of distributing protein aggregates among microglial networks.

机构信息

Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

出版信息

Neuron. 2021 Oct 20;109(20):3228-3230. doi: 10.1016/j.neuron.2021.10.008.

DOI:10.1016/j.neuron.2021.10.008

Abstract

The trafficking of protein aggregates through neural circuitries causes adverse outcomes, including propagation of pathology and toxicity in neurodegenerative diseases. In a recent issue of Cell, Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy in microglial networks that nurtures α-synuclein-loaded members back to health.

摘要

蛋白质聚集体在神经回路中的运输会导致不良后果，包括神经退行性疾病中病理学和毒性的传播。在最近一期的《细胞》杂志上，Scheiblich 等人（2021）描述了小神经胶质细胞网络中一种有利的聚集体共享策略，该策略可使载有α-突触核蛋白的成员恢复健康。