Key Laboratory of Plant Nutrition and the Agri-Environment in Northwest China, Ministry of Agriculture, College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210093, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210093, China.
Chemosphere. 2022 Jan;287(Pt 4):132412. doi: 10.1016/j.chemosphere.2021.132412. Epub 2021 Sep 29.
Microplastics (MPs) in the environment would undergo extensive weathering, which can act as a vector affecting the accumulation of pollutants in organisms. However, the risk of organic pollutants adsorbed on aged MPs to marine organisms is poorly understood. This study revealed the contribution of aged polystyrene (PS) MPs to the total bioaccumulation of atorvastatin (ATV) and amlodipine (AML), and assessed the environmental risks via experimental and model analysis. The results showed that pharmaceuticals were more easily released in gastrointestinal fluids from aged MPs relative to that in simulated seawater. The hydrophobic pharmaceuticals were more bioaccessible than hydrophilic ones by organisms. Model analysis showed that ingestion of water and food were the most important uptake routes for pharmaceuticals in marine fish and seabirds, while aged PS MPs could decrease the bioaccumulation of pharmaceuticals (contributed for -2.9% and -1.2% for the total uptake of ATV, and -25.8% and -4.4% for AML), indicating the cleaning effect of aged MPs, and the potential higher exposure risks of pharmaceuticals in warm-blooded organisms than that in cold-blooded ones via ingested MPs. The study revealed the effect of aged MPs to the bioaccumulation of pharmaceuticals in marine organisms, and highlighted the combined risks of aged MPs and pharmaceuticals in the environment.
环境中的微塑料（MPs）会经历广泛的风化，这可能成为影响污染物在生物体内积累的一个因素。然而，对于吸附在老化 MPs 上的有机污染物对海洋生物的风险，人们知之甚少。本研究通过实验和模型分析，揭示了老化聚苯乙烯（PS） MPs 对阿托伐他汀（ATV）和氨氯地平（AML）总生物累积的贡献，并评估了其环境风险。结果表明，与模拟海水中相比，老化 MPs 中的药物在胃肠道液体中更容易释放。亲脂性药物比亲水性药物更容易被生物利用。模型分析表明，在海洋鱼类和海鸟中，摄入水和食物是药物的最重要摄取途径，而老化 PS MPs 可降低药物的生物累积（对 ATV 的总摄取量分别减少 2.9%和 1.2%，对 AML 减少 25.8%和 4.4%），表明老化 MPs 具有清洁作用，并且通过摄入 MPs，温血生物比冷血生物面临更高的药物暴露风险。本研究揭示了老化 MPs 对海洋生物中药物生物累积的影响，强调了环境中老化 MPs 和药物的综合风险。
