青少年和年轻成人弥漫性大 B 细胞淋巴瘤幸存者的长期生存差异。
Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors.
机构信息
Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Division of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Cancer Epidemiol. 2021 Dec;75:102044. doi: 10.1016/j.canep.2021.102044. Epub 2021 Sep 28.
PURPOSE
The population of adolescent and young adult (AYA, ages 15-39 years) diffuse large B-cell lymphoma (DLBCL) survivors is growing, however long-term overall survival patterns and disparities are largely unknown.
METHODS
The current study utilized the Surveillance, Epidemiology, and End Results (SEER) registry to assess the impact of race/ethnicity, sex, socioeconomic status, and rurality on long-term survival in 5-year DLBCL survivors using an accelerated failure time model.
RESULTS
Included were 4767 5-year survivors of AYA DLBCL diagnosed between the years 1980 and 2009 with a median follow-up time of 13.4 years. Non-Hispanic Black survivors had significantly worse long-term survival than non-Hispanic White survivors (Survival Time Ratio (STR): 0.53, p < 0.0001). Male sex (STR: 0.57, p < 0.0001) and older age at diagnosis were also associated with reduced long-term survival. There was no evidence that survival disparities improved over time.
CONCLUSIONS
Racial disparities persist well into survivorship among AYA DLBCL survivors. Studies investigating specific factors associated with survival disparities are urgently needed to better address these disparities.
目的
青少年和年轻成人（AYA，年龄 15-39 岁）弥漫性大 B 细胞淋巴瘤（DLBCL）幸存者的人数不断增加，但长期总体生存模式和差异在很大程度上尚不清楚。
方法
本研究利用监测、流行病学和最终结果（SEER）登记处，使用加速失效时间模型评估种族/民族、性别、社会经济地位和农村地区对 5 年 DLBCL 幸存者长期生存的影响。
结果
纳入了 1980 年至 2009 年间诊断为 AYA DLBCL 的 4767 名 5 年幸存者，中位随访时间为 13.4 年。非西班牙裔黑人幸存者的长期生存明显差于非西班牙裔白人幸存者（生存时间比（STR）：0.53，p<0.0001）。男性（STR：0.57，p<0.0001）和诊断时年龄较大也与长期生存降低有关。没有证据表明生存差异随着时间的推移而改善。
结论
在 AYA DLBCL 幸存者的生存中，种族差异仍然存在。迫切需要研究与生存差异相关的具体因素，以更好地解决这些差异。
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