Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan.
School of Medicine, Tzu Chi University, Hualien City, Taiwan.
BMC Complement Med Ther. 2021 Oct 1;21(1):247. doi: 10.1186/s12906-021-03416-w.
This study aimed to investigate the prevalence of and the factors associated with the regular use of complementary therapies for Taiwanese patients with systemic lupus erythematosus (SLE).
In this cross-sectional study, 351 patients with SLE were consecutively recruited from a regional hospital in southern Taiwan from April to August 2019. Demographic and clinical information, including the use of different types of complementary therapies, was ascertained using a self-constructed questionnaire. Disease-specific quality of life was measured using the Lupus Quality of Life (LupusQoL) questionnaire. SLE disease activity was assessed using the rheumatologist-scored Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K). Factors associated with the regular use of complementary therapies were evaluated using multiple logistic regression analyses.
Of the 351 patients with SLE, 90.3% were female, and 60.1% were ≥ 40 years of age. The prevalence of the regular use of any type of complementary therapy was 85.5%. The five most popular types of complementary therapy used were (1) fitness walking or strolling, (2) Buddhist prayer or attending temple, (3) vitamin consumption, (4) calcium supplementation, and (5) fish oil supplementation. Multiple logistic regression analyses revealed that the significant and independent factors associated with the regular use of complementary therapies in patients with SLE were age ≥ 40 years (adjusted odds ratio [aOR] 2.76, p = 0.013), nonoverweight or nonobesity (aOR 0.29, p = 0.004), engagement in vigorous exercise in the past year (aOR 4.62, p = 0.002), a lower SLEDAI-2 K score (aOR 0.90, p = 0.029), and a lower score in the physical health domain of the LupusQoL (aOR 0.57, p = 0.001).
A high prevalence of complementary therapy use in Taiwanese patients with SLE was observed. Rheumatologists should routinely ask patients about their use of supplements to minimize the risk of interaction with medical therapy.
本研究旨在调查台湾系统性红斑狼疮（SLE）患者定期使用补充疗法的流行情况和相关因素。
在这项横断面研究中，2019 年 4 月至 8 月，连续招募了来自台湾南部一家地区医院的 351 名 SLE 患者。使用自我构建的问卷确定人口统计学和临床信息，包括不同类型的补充疗法的使用情况。使用狼疮生活质量（LupusQoL）问卷测量疾病特异性生活质量。使用风湿病学家评分的系统性红斑狼疮疾病活动指数 2000（SLEDAI-2K）评估 SLE 疾病活动。使用多元逻辑回归分析评估与定期使用补充疗法相关的因素。
在 351 名 SLE 患者中，90.3%为女性，60.1%年龄≥40 岁。定期使用任何类型的补充疗法的患病率为 85.5%。使用最多的五种补充疗法分别是：（1）健身散步或闲逛，（2）拜佛或去寺庙，（3）维生素摄入，（4）钙补充，（5）鱼油补充。多元逻辑回归分析显示，与 SLE 患者定期使用补充疗法相关的显著和独立因素是年龄≥40 岁（调整后的优势比[aOR]2.76，p=0.013），非超重或非肥胖（aOR0.29，p=0.004），过去一年进行剧烈运动（aOR4.62，p=0.002），SLEDAI-2K 评分较低（aOR0.90，p=0.029），LupusQoL 生理健康领域得分较低（aOR0.57，p=0.001）。
台湾 SLE 患者补充疗法的使用率很高。风湿病学家应常规询问患者补充剂的使用情况，以最大程度地降低与药物治疗相互作用的风险。
