Liu Liu, Zhang Lei, Li Ming
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.
Front Pharmacol. 2022 Nov 24;13:981063. doi: 10.3389/fphar.2022.981063. eCollection 2022.
Lupus nephritis (LN) is a secondary renal disease caused by systemic lupus erythematosus affecting the kidneys. It is one of the main causes of end-stage renal disease and a serious risk factor for early mortality and disability of systemic lupus erythematosus patients. Existing LN treatment is mainly based on hormones, cytotoxic drugs, and biological agents. Nevertheless, the prognosis of LN patients remains poor because of frequent recurrence and exacerbation of adverse drug reactions. Hence, LN is still the most important cause of end-stage renal disease. In recent years, traditional Chinese medicine (TCM) has attracted increasing attention because of encouraging evidence that it alleviates LN and the well-described mechanisms underlying renal injury. TCM has therapeutic benefits for treating LN patients. This review article elucidates TCM preparations, TCM monomers, and herbal or natural extraction for LN treatment to provide effective supplementary evidence for promoting the development of TCM treatment for LN and reference for future research and clinical practice.
狼疮性肾炎（LN）是一种由系统性红斑狼疮累及肾脏所致的继发性肾脏疾病。它是终末期肾病的主要病因之一，也是系统性红斑狼疮患者早期死亡和致残的严重危险因素。现有的LN治疗主要基于激素、细胞毒性药物和生物制剂。然而，由于LN患者频繁复发以及药物不良反应的加重，其预后仍然较差。因此，LN仍是终末期肾病的最重要病因。近年来，中医药因其在缓解LN方面的令人鼓舞的证据以及对肾损伤潜在机制的详细描述而受到越来越多的关注。中医药对治疗LN患者具有治疗益处。这篇综述文章阐明了用于LN治疗的中药制剂、中药单体以及草药或天然提取物，为促进LN的中医药治疗发展提供有效的补充证据，并为未来的研究和临床实践提供参考。
