AXL在转移性肾细胞癌中不断演变的作用
An Evolving Role for AXL in Metastatic Renal Cell Carcinoma.
作者信息
Hahn Andrew W, George Daniel J, Agarwal Neeraj
机构信息
Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
出版信息
Clin Cancer Res. 2021 Dec 15;27(24):6619-6621. doi: 10.1158/1078-0432.CCR-21-3029. Epub 2021 Oct 1.
High tumoral expression of AXL was associated with inferior response to anti-PD-1 therapy and increased tumoral programmed death ligand 1 (PD-L1) expression in patients with metastatic renal cell carcinoma, with particularly poor outcomes in those with high AXL and PD-L1. AXL expression has potential as a biomarker and therapeutic target..
在转移性肾细胞癌患者中，AXL的高肿瘤表达与抗PD-1治疗反应较差以及肿瘤程序性死亡配体1（PD-L1）表达增加相关，AXL和PD-L1水平高的患者预后尤其差。AXL表达有潜力作为一种生物标志物和治疗靶点。
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