与新斯的明相比，舒更葡糖可缩短腹部手术后在麻醉后恢复室的恢复时间。

Sugammadex Reduces PACU Recovery Time after Abdominal Surgery Compared with Neostigmine.

作者信息

Deng Jin, Balouch Maha, Albrink Michael, Camporesi Enrico M

机构信息

From the Morsani College of Medicine, University of South Florida, Tampa, TEAMHealth Anesthesia, Tampa, Florida, and the Division of General Surgery, Tampa General Hospital, Tampa, Florida.

出版信息

South Med J. 2021 Oct;114(10):644-648. doi: 10.14423/SMJ.0000000000001304.

DOI:10.14423/SMJ.0000000000001304

PMID:34599343

Abstract

OBJECTIVE

This study blindly evaluated sugammadex compared with neostigmine on length of stay in the postanesthesia care unit (PACU).

METHODS

Fifty patients undergoing elective laparoscopic cholecystectomy or abdominal wall hernia repair consented to receive either sugammadex (2 mg/kg) or neostigmine (0.07 mg/kg) for the reversal of rocuronium neuromuscular blockade. Reversal agents were administered during surgical closing, and the train of four was measured until a twitch ratio of T4:T1 ≥ 0.9 was obtained to signify a robust reversal. Postreversal outcomes also were measured during PACU stay. Aldrete scores, pain visual analog scale score, and nausea were measured during the PACU stay.

RESULTS

Patients receiving sugammadex experienced a shorter PACU stay at the time of discharge than patients receiving neostigmine, by an average of 12 minutes ( < 0.05).

CONCLUSIONS

Sugammadex patients had a significantly shorter PACU stay.

摘要

目的

本研究对舒更葡糖钠与新斯的明在麻醉后恢复室（PACU）的住院时间进行了盲法评估。

方法

50例行择期腹腔镜胆囊切除术或腹壁疝修补术的患者同意接受舒更葡糖钠（2mg/kg）或新斯的明（0.07mg/kg）用于逆转罗库溴铵的神经肌肉阻滞。在手术结束时给予逆转剂，并测量四个成串刺激，直至获得T4:T1≥0.9的颤搐比以表明有效的逆转。在PACU停留期间也测量逆转后的结果。在PACU停留期间测量Aldrete评分、疼痛视觉模拟量表评分和恶心情况。