Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
The Key Laboratory for Reproductive Medicine of Guangdong Province, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Andrologia. 2022 Feb;54(1):e14262. doi: 10.1111/and.14262. Epub 2021 Oct 2.
Reciprocal translocation and Robertsonian translocation are known to be causative factors of male infertility. However, the association between autosomal reciprocal translocation, Robertsonian translocation and semen parameters remains controversial. We performed a retrospective study and systematic review to investigate semen parameters in patients with autosomal reciprocal translocation or Robertsonian translocation. We recruited a total of 1,033 controls, 723 reciprocal translocation carriers and 326 Robertsonian translocation carriers. Men in the control, reciprocal translocation and Robertsonian translocation groups had a median age of 32.0 (95% CI, 32.0-33.0), 32.0 (95% CI, 32.0-33.0) and 33.0 (95% CI, 32.0-33.0) years respectively. Results showed that sperm concentration, total number per ejaculate, total motility, progressive motility of autosomal reciprocal translocation and Robertsonian translocation carriers were statistically lower than controls (p < .001). Eleven studies featuring 794 patients were enrolled in this systematic review. Compared with controls, autosomal reciprocal translocation and Robertsonian translocation carriers showed lower sperm concentration, total motility, progressive motility and normal morphology. Our results support the conclusion that sperm concentration, total number per ejaculate, total motility and progressive motility are significantly lower in autosomal reciprocal translocation and Robertsonian translocation carriers than in controls.
相互易位和罗伯逊易位已知是男性不育的致病因素。然而，常染色体相互易位、罗伯逊易位与精液参数之间的关联仍存在争议。我们进行了一项回顾性研究和系统评价，以调查常染色体相互易位或罗伯逊易位患者的精液参数。我们共招募了 1033 名对照、723 名相互易位携带者和 326 名罗伯逊易位携带者。对照组、相互易位组和罗伯逊易位组的男性年龄中位数分别为 32.0（95%CI，32.0-33.0）、32.0（95%CI，32.0-33.0）和 33.0（95%CI，32.0-33.0）岁。结果显示，常染色体相互易位和罗伯逊易位携带者的精子浓度、每次射精的总数、总活力、前向运动活力均明显低于对照组（p<0.001）。本系统评价共纳入 11 项研究，共 794 例患者。与对照组相比，常染色体相互易位和罗伯逊易位携带者的精子浓度、总活力、前向运动活力和正常形态均较低。我们的结果支持以下结论：常染色体相互易位和罗伯逊易位携带者的精子浓度、每次射精的总数、总活力和前向运动活力明显低于对照组。
