Department of Paediatric Gastroenterology, Evelina London Children's Hospital, London, UK.
Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK.
Acta Gastroenterol Belg. 2021 Jul-Sep;84(3):429-434. doi: 10.51821/84.3.002.
Intestinal pseudo obstruction both acute and chronic is an uncommon severe motility disorder that affect both children and adults, can lead to significant morbidity burden and have no standard management strategy. Prucalopride a highly selective serotonin receptor agonist is an effective laxative with reported extra colon action. We aim to report our experience in children with acute and chronic intestinal pseudo obstruction who responded to prucalopride and systemically review the use of prucalopride in intestinal pseudo obstruction.
A report of clinical experience and systemic review of the relevant medical databases to identify the outcome of usage of prucalopride in patients with acute and chronic intestinal pseudo obstruction. Studies meeting the selection criteria were reviewed including abstract only and case reports.
All reported cases showed clinical response to prucalopride. There were three full text, two abstracts only and three case reports all reporting clinical improvement with prucalopride.
Prucalopride appears to show promising results in children and adults with acute and chronic intestinal pseudo obstruction.
肠假性梗阻无论是急性还是慢性，都是一种罕见的严重运动障碍，可影响儿童和成人，可导致严重的发病率负担，且没有标准的管理策略。普芦卡必利是一种高度选择性的 5-羟色胺受体激动剂，是一种有效的泻药，据报道对结肠外也有作用。我们旨在报告对接受普芦卡必利治疗的急性和慢性肠假性梗阻儿童的经验，并对普芦卡必利在肠假性梗阻中的应用进行系统回顾。
报告临床经验和对相关医学数据库进行系统回顾，以确定普芦卡必利在急性和慢性肠假性梗阻患者中的使用效果。符合选择标准的研究包括摘要和病例报告。
所有报告的病例均对普芦卡必利有临床反应。有 3 篇全文、2 篇摘要和 3 篇病例报告均报告了普芦卡必利治疗的临床改善。
普芦卡必利似乎对儿童和成人的急性和慢性肠假性梗阻有较好的效果。
