Biology Department, Université de Moncton, Moncton, NB, E1A 3E9, Canada.
Endocrine. 2021 Dec;74(3):498-507. doi: 10.1007/s12020-021-02888-7. Epub 2021 Oct 2.
Members of the AP-1 family of transcription factors are immediate early genes being modulated by different extracellular signals. The aim of this review is to highlight the important roles of AP-1 members in transcriptional regulation of genes important for testicular Leydig cell function and male testosterone production.
A search of the relevant literature was performed in Google Scholar and NCBI Pubmed for AP-1 members and Leydig cells. Additional information was accessed from references of relevant articles. Only primary data from original peer-reviewed articles was considered for this review.
Different signaling pathways important for Leydig cells' functions are involved in the regulation of the activity of AP-1 members. These transcription factors participate in the regulation of genes related to different biological processes important for Leydig cells.
We conclude that members of the AP-1 family of transcription factors play critical roles in the regulation of Leydig cell proliferation, steroidogenesis, and cell-to-cell communication.
AP-1 家族的转录因子是即时早期基因，可被不同的细胞外信号调节。本综述的目的是强调 AP-1 成员在调节与睾丸间质细胞功能和男性睾酮产生有关的基因的转录中的重要作用。
在 Google Scholar 和 NCBI Pubmed 上搜索了与 AP-1 成员和间质细胞相关的文献。从相关文章的参考文献中获取了其他信息。本综述仅考虑了原始同行评审文章的原始数据。
参与调节间质细胞功能的不同信号通路参与了 AP-1 成员活性的调节。这些转录因子参与调节与间质细胞重要的不同生物学过程相关的基因。
我们得出结论，AP-1 家族的转录因子在调节间质细胞增殖、类固醇生成和细胞间通讯中起着关键作用。
