Biology Department, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Int J Mol Sci. 2022 Oct 25;23(21):12887. doi: 10.3390/ijms232112887.
Transcription factors members of the basic leucine zipper (bZIP) class play important roles in the regulation of genes and functions in testicular Leydig cells. Many of these factors, such as cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB), are regulated by the cAMP/protein kinase A (PKA) pathway, the main signaling pathway activated following the activation of the luteinizing hormone/choriogonadotropin membrane receptor LHCGR by the - hormone LH. Others, such as X-box binding protein 1 (XBP1) and members of the cAMP responsive element binding protein 3 (CREB3)-like superfamily, are implicated in the endoplasmic reticulum stress by regulating the unfolded protein response. In this review, the influences of bZIP transcription factors, including CREB1, CEBPB and activator protein 1 (AP-1) family members, on the regulation of genes important for cell proliferation, steroidogenesis and Leydig cell communication will be covered. In addition, unresolved questions regarding the mechanisms of actions of bZIP members in gene regulation will be identified.
转录因子是碱性亮氨酸拉链（bZIP）家族的成员，在睾丸间质细胞中基因调控和功能方面发挥着重要作用。这些因子中的许多，如环磷酸腺苷反应元件结合蛋白 1（CREB1）和 CCAAT 增强子结合蛋白β（CEBPB），受环磷酸腺苷/蛋白激酶 A（PKA）途径调控，该途径是黄体生成素/绒毛膜促性腺激素膜受体 LHCGR 被激素 LH 激活后主要的信号转导途径。其他一些因子，如 X 盒结合蛋白 1（XBP1）和 cAMP 反应元件结合蛋白 3（CREB3）样超家族成员，通过调节未折叠蛋白反应与内质网应激有关。在这篇综述中，将介绍 bZIP 转录因子（包括 CREB1、CEBPB 和激活蛋白 1（AP-1）家族成员）对细胞增殖、类固醇生成和 Leydig 细胞通讯的重要基因调控的影响。此外，还将确定 bZIP 成员在基因调控中的作用机制方面存在的未解决问题。
