新型血清生物标志物模型由骨转换标志物、维生素 D 和雌二醇组成，及其在特发性中枢性性早熟女孩中的辅助诊断价值。
Novel serological biomarker models composed of bone turnover markers, vitamin D, and estradiol and their auxiliary diagnostic value in girls with idiopathic central precocious puberty.
机构信息
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No. 20, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, China; The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, China; West China School of Medicine, Sichuan University, No. 17, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, China.
出版信息
Bone. 2022 Jan;154:116221. doi: 10.1016/j.bone.2021.116221. Epub 2021 Sep 30.
OBJECTIVE
To establish serological biomarker models composed of bone turnover markers (BTMs), vitamin D (Vit D), and estradiol (E2) and to explore their auxiliary diagnostic value in girls with idiopathic central precocious puberty (ICPP).
METHODS
Ninety-three girls with ICPP and 93 healthy girls were included in the ICPP group and the control group, respectively. The serum levels of total procollagen type 1 N-terminal propeptide (P1NP), N-terminal midfragment of osteocalcin (N-MID), β-C-terminal telopeptide of type 1 collagen (β-CTX), Vit D, E2, and other biochemical parameters were detected in all participants. Serological biomarker models for assistance with ICPP diagnosis were established by logistic regression analyses.
RESULTS
Serum P1NP, β-CTX, Vit D, and E2 levels differed significantly between the two groups (p < 0.05). Three models were established. Model 1 consisted of P1NP and β-CTX, and had an area under curve (AUC) of 0.764, sensitivity of 74.19%, and specificity of 72.04%. Model 2 consisted of P1NP, β-CTX, and Vit D, and had an AUC of 0.840, sensitivity of 83.87%, and specificity of 72.04%. Model 3 consisted of P1NP, β-CTX, Vit D, and E2, and had an AUC of 0.917, sensitivity of 82.80%, and specificity of 86.02%.
CONCLUSIONS
Serum P1NP, β-CTX, Vit D, and E2 levels may be effective indicators for auxiliary diagnosis of ICPP. Serological biomarker models composed of P1NP, β-CTX, Vit D, and E2 (models 1, 2, and 3) may have auxiliary diagnostic value for ICPP.
目的
建立由骨转换标志物（BTMs）、维生素 D（Vit D）和雌二醇（E2）组成的血清生物标志物模型，并探讨其在特发性中枢性性早熟（ICPP）女孩中的辅助诊断价值。
方法
分别纳入 93 例 ICPP 女孩和 93 名健康女孩作为 ICPP 组和对照组，检测所有参与者的血清总Ⅰ型前胶原 N 端前肽（P1NP）、骨钙素 N 端中段（N-MID）、Ⅰ型胶原β-C 端肽（β-CTX）、Vit D、E2 等生化参数。采用 logistic 回归分析建立用于辅助诊断 ICPP 的血清生物标志物模型。
结果
两组血清 P1NP、β-CTX、Vit D、E2 水平差异均有统计学意义（p<0.05）。建立了 3 个模型。模型 1 由 P1NP 和 β-CTX 组成，曲线下面积（AUC）为 0.764，灵敏度为 74.19%，特异性为 72.04%。模型 2 由 P1NP、β-CTX 和 Vit D 组成，AUC 为 0.840，灵敏度为 83.87%，特异性为 72.04%。模型 3 由 P1NP、β-CTX、Vit D 和 E2 组成，AUC 为 0.917，灵敏度为 82.80%，特异性为 86.02%。
结论
血清 P1NP、β-CTX、Vit D 和 E2 水平可能是辅助诊断 ICPP 的有效指标。由 P1NP、β-CTX、Vit D 和 E2 组成的血清生物标志物模型（模型 1、2 和 3）对 ICPP 可能具有辅助诊断价值。
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