Lee Y S
Pathology. 1986 Jan;18(1):35-40. doi: 10.3109/00313028609090825.
This study aims to establish the pattern of muscle diseases in Singapore. Two hundred consecutive muscle biopsies collected prospectively over a period of 7 yr (1978-1984) were studied using light microscopy, histochemistry and electron microscopy. Muscle diseases were not uncommon. There was no racial predilection. The common muscle diseases were polymyositis, spinal muscular atrophies and muscular dystrophies. Less common ones included congenital myopathies and storage diseases due to disorders of glycogen and lipid metabolism. Other muscle diseases were uncommon. Polymyositis was the commonest muscular disorder in adults and spinal muscular atrophy in childhood. This finding is encouraging as polymyositis is a treatable condition. The common occurrence of spinal muscular atrophies in this country was not fully appreciated. They were often misdiagnosed clinically as muscular dystrophies. It is hoped that this finding will result in greater awareness of this condition which is necessary for proper genetic counselling and management.
本研究旨在确立新加坡肌肉疾病的模式。对在7年期间（1978 - 1984年）前瞻性收集的200例连续肌肉活检样本，采用光学显微镜、组织化学和电子显微镜进行研究。肌肉疾病并不罕见。不存在种族倾向。常见的肌肉疾病有多发性肌炎、脊髓性肌萎缩症和肌营养不良症。较不常见的包括先天性肌病以及糖原和脂质代谢紊乱导致的贮积病。其他肌肉疾病则较为罕见。多发性肌炎是成人中最常见的肌肉疾病，而脊髓性肌萎缩症在儿童中较为常见。这一发现令人鼓舞，因为多发性肌炎是一种可治疗的疾病。该国脊髓性肌萎缩症的常见情况此前未得到充分认识。它们在临床上常被误诊为肌营养不良症。希望这一发现能提高对这种疾病的认识，这对于进行适当的遗传咨询和管理是必要的。
