影响电子传递蛋白氧化还原电位的因素。
Factors influencing redox potentials of electron transfer proteins.
作者信息
Moore G R, Pettigrew G W, Rogers N K
出版信息
Proc Natl Acad Sci U S A. 1986 Jul;83(14):4998-9. doi: 10.1073/pnas.83.14.4998.
Abstract
The redox potentials of electron transfer proteins vary over a wide range, even when the type of redox center is the same. Rees [Proc. Natl. Acad. Sci. USA (1985) 82, 3082-3085] proposed that this variation of redox potential partly reflects the different net charges of the proteins, and he presented a linear correlation between these two properties for 36 proteins. A review of the factors that influence protein redox potentials makes it clear that this linear correlation is fortuitous. The key factors influencing redox potentials are the contributions to the Gibbs energy difference between the two redox states, resulting from bonding interactions at the redox center, electrostatic interactions between the redox-center charge and polar groups within the protein and solvent, and redox-state conformational changes. The relative importance of these terms is likely to vary from protein to protein.
摘要
即使氧化还原中心的类型相同，电子传递蛋白的氧化还原电位也会在很宽的范围内变化。里斯[《美国国家科学院院刊》(1985年)82卷，3082 - 3085页]提出，这种氧化还原电位的变化部分反映了蛋白质不同的净电荷，并且他给出了36种蛋白质这两种性质之间的线性相关性。对影响蛋白质氧化还原电位的因素进行综述后可以清楚地看出，这种线性相关性是偶然的。影响氧化还原电位的关键因素是氧化还原中心的键合相互作用、氧化还原中心电荷与蛋白质和溶剂中的极性基团之间的静电相互作用以及氧化还原状态的构象变化对两种氧化还原状态之间吉布斯自由能差的贡献。这些因素的相对重要性可能因蛋白质而异。
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