三阴性乳腺癌中的非编码 RNA：化疗耐药的机制。
Noncoding RNAs in triple negative breast cancer: Mechanisms for chemoresistance.
机构信息
Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China.
Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China; Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China.
出版信息
Cancer Lett. 2021 Dec 28;523:100-110. doi: 10.1016/j.canlet.2021.09.038. Epub 2021 Sep 30.
Triple-negative breast cancer (TNBC) is the most aggressive subtype among breast cancers with high recurrence and this condition is partly due to chemoresistance. Therefore, fully understanding the mechanism of TNBC-resistance is the key to overcoming chemoresistance, which will be an effective strategy for TNBC therapy. Various potential mechanisms involved in the chemoresistance of TNBC have been investigated and indicated that noncoding RNAs (ncRNAs) especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) take part in most TNBC resistance. The ncRNA-induced chemoresistance process is involved in the alteration of many activities. here, we mainly summarize the mechanisms of ncRNAs in the chemoresistance of TNBC and discuss the potential clinical application of ncRNAs in the treatment of TNBC, indicating that targeting ncRNAs might be a promising strategy for resensitization to chemotherapies.
三阴性乳腺癌（TNBC）是乳腺癌中最具侵袭性的亚型，具有较高的复发率，这种情况部分归因于化疗耐药。因此，充分了解 TNBC 耐药的机制是克服化疗耐药的关键，这将是 TNBC 治疗的有效策略。已经研究了各种与 TNBC 耐药相关的潜在机制，并表明非编码 RNA（ncRNA），特别是 microRNAs（miRNAs）、长非编码 RNA（lncRNA）和环状 RNA（circRNA）参与了大多数 TNBC 耐药。ncRNA 诱导的耐药过程涉及许多活性的改变。在这里，我们主要总结了 ncRNAs 在 TNBC 耐药中的作用机制，并讨论了 ncRNAs 在 TNBC 治疗中的潜在临床应用，表明靶向 ncRNAs 可能是重新敏化化疗的有前途的策略。
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