School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Pharmacol Res. 2021 Dec;174:105919. doi: 10.1016/j.phrs.2021.105919. Epub 2021 Oct 1.
With the coming of the era of the aging population, hypertension has become a global health burden to be dealt with. Although there are multiple drugs and procedures to control the symptoms of hypertension, the management of it is still a long-term process, and the side effects of conventional drugs pose a burden on patients. Flavonoids, common compounds found in fruits and vegetables as secondary metabolites, are active components in Chinese Herbal Medicine. The flavonoids are proved to have cardiovascular benefits based on a plethora of animal experiments over the last decade. Thus, the flavonoids or flavonoid-rich plant extracts endowed with anti-hypertension activities and probable mechanisms were reviewed. It has been found that flavonoids may affect blood pressure in various ways. Moreover, despite the substantial evidence of the potential for flavonoids in the control of hypertension, it is not sufficient to support the clinical application of flavonoids as an adjuvant or core drug. So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion. It is believed that more breakthrough studies are needed. Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.
随着人口老龄化时代的到来，高血压已成为全球需要应对的健康负担。尽管有多种药物和程序可以控制高血压的症状，但对其的管理仍然是一个长期的过程，而且常规药物的副作用给患者带来了负担。类黄酮是水果和蔬菜中作为次生代谢物的常见化合物，是中药的活性成分。基于过去十年的大量动物实验，证明类黄酮具有心血管益处。因此，综述了具有抗高血压活性和可能机制的类黄酮或富含类黄酮的植物提取物。已经发现，类黄酮可能通过多种方式影响血压。此外，尽管有大量证据表明类黄酮在控制高血压方面具有潜力，但还不足以支持将类黄酮作为辅助药物或核心药物应用于临床。因此，类黄酮与其他药物的协同作用、药代动力学研究、临床试验以及类黄酮的安全性也纳入了讨论。相信还需要更多突破性的研究。总的来说，这项综述可能会为明确认识类黄酮的抗高血压作用机制提供一些新的思路，指出现阶段相关研究的局限性和今后研究应加强的方面。
