Shirazi Talia N, Self Heather, Dawood Khytam, Welling Lisa L M, Cárdenas Rodrigo, Rosenfield Kevin A, Bailey J Michael, Balasubramanian Ravikumar, Delaney Angela, Breedlove S Marc, Puts David A
Department of Anthropology, Pennsylvania State University, Carpenter Building, University Park, PA 16802, USA.
Department of Psychology, Pennsylvania State University, Moore Building, University Park, PA 16802, USA.
Psychoneuroendocrinology. 2021 Sep 27;134:105431. doi: 10.1016/j.psyneuen.2021.105431.
Ovarian estrogens may influence the development of the human brain and behavior, but there are few opportunities to test this possibility. Isolated GnRH deficiency (IGD) is a rare endocrine disorder that could provide evidence for the role of estrogens in organizing sexually differentiated phenotypes: Unlike typical development, development in individuals with IGD is characterized by low or absent gonadal hormone production after the first trimester of gestation. Because external genitalia develop in the first trimester, external appearance is nevertheless concordant with gonadal sex in people with IGD. We therefore investigated the effects of gonadal hormones on sexual orientation by comparing participants with IGD (n = 97) to controls (n = 1670). Women with IGD reported lower male-attraction compared with typically developing women. In contrast, no consistent sexuality differences between IGD and typically developing men were evident. Ovarian hormones after the first trimester appear to influence female-typical dimensions of sexual orientation.
卵巢雌激素可能会影响人类大脑和行为的发育，但几乎没有机会来验证这种可能性。孤立性促性腺激素释放激素缺乏症（IGD）是一种罕见的内分泌疾病，它可能为雌激素在组织性分化表型中的作用提供证据：与典型发育不同，IGD患者在妊娠头三个月后性腺激素分泌较低或缺乏。由于外生殖器在头三个月发育，因此IGD患者的外观与性腺性别一致。因此，我们通过比较IGD患者（n = 97）和对照组（n = 1670）来研究性腺激素对性取向的影响。与发育正常的女性相比，IGD女性报告对男性的吸引力较低。相比之下，IGD男性和发育正常的男性之间没有明显一致的性取向差异。妊娠头三个月后的卵巢激素似乎会影响性取向中女性典型的维度。
