Belay Demeke Mesfin, Bayih Wubet Alebachew, Alemu Abebaw Yeshambel, Sinshaw Aklilu Endalamaw, Mekonen Demewoz Kefale, Ayele Amare Simegn, Aytenew Tigabu Munye, Aynew Yeshambaw Eshetie, Hailemichael Wasihun, Getu Sisay, Kiros Mulugeta, Andualem Henok, Birihan Binyam Minuye
Department of Pediatrics and Child Health Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Maternity and Neonatal Health Nursing, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Trop Med Int Health. 2021 Dec;26(12):1539-1552. doi: 10.1111/tmi.13684. Epub 2021 Oct 12.
To estimate the prevalence of macrosomia and contributing factors among pregnant women with diabetes in Ethiopia.
The Cochrane, PubMed, Google Scholar, SCOPUS, Web of Science electronic databases and grey literature found in online university repositories were searched for primary studies reporting the prevalence of macrosomia (birth weight ≥4 kg, irrespective of gestational age) and/or at least one determinant factor using WHO diabetes diagnosis criteria were involved. Variations across the studies were checked using the I statistic; funnel plot and Egger's test were used to assess publication bias. A weighted inverse random effect model was used to estimate the overall prevalence of macrosomia.
The overall prevalence of macrosomic newborns among pregnant women with diabetes [15.1% (95% CI: 9.0%, 21.2%)] was higher than the prevalence among non-diabetic mothers (3.9%). Maternal blood glucose level >100 mg/dl [AOR = 10.5: 95% CI: 5.9, 15.1] and >120 mg/dl [AOR = 8.8: 95% CI: 4.5, 13.0], lack of Antenatal Care (ANC) visit [AOR = 10.8: 95% CI: 6.0, 15.0], previous adverse birth outcomes and advanced maternal age [AOR = 3.5: 95% CI: 1.0, 5.9] were significantly associated with the prevalence of macrosomia at 95% CI.
The pooled prevalence of macrosomia among pregnant women with diabetes was higher than the prevalence among non-diabetic pregnant women (3.9%). Advanced maternal age, previous adverse birth outcomes, lack of ANC and uncontrolled maternal plasma glucose level were independent predictors of macrosomia.
评估埃塞俄比亚糖尿病孕妇中巨大儿的患病率及相关因素。
检索Cochrane、PubMed、谷歌学术、SCOPUS、科学网电子数据库以及在线大学知识库中的灰色文献，查找报告巨大儿患病率（出生体重≥4千克，不论孕周）和/或使用世界卫生组织糖尿病诊断标准的至少一个决定因素的原始研究。使用I统计量检查研究间的差异；漏斗图和Egger检验用于评估发表偏倚。采用加权逆随机效应模型估计巨大儿的总体患病率。
糖尿病孕妇中巨大儿新生儿的总体患病率[15.1%（95%置信区间：9.0%，21.2%）]高于非糖尿病母亲中的患病率（3.9%）。孕妇血糖水平>100毫克/分升[AOR = 10.5：95%置信区间：5.9，15.1]和>120毫克/分升[AOR = 8.8：95%置信区间：4.5，13.0]、未进行产前检查（ANC）[AOR = 10.8：95%置信区间：6.0，15.0]、既往不良分娩结局和高龄产妇[AOR = 3.5：95%置信区间：1.0，5.9]与95%置信区间下的巨大儿患病率显著相关。
糖尿病孕妇中巨大儿的合并患病率高于非糖尿病孕妇（3.9%）。高龄产妇、既往不良分娩结局、未进行产前检查和孕妇血浆葡萄糖水平控制不佳是巨大儿的独立预测因素。
