Department of Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Pediatrics and Child Health Nursing, School of Health Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
PLoS One. 2020 Nov 10;15(11):e0241811. doi: 10.1371/journal.pone.0241811. eCollection 2020.
The magnitude of adverse birth outcome among diabetic pregnant women is high in low-and-middle income countries, like Ethiopia. Precise epidemiological evidence is necessary to plan, evaluate and improve effective preventive measures. This systematic review and meta-analysis is the first to estimate the pooled prevalence of adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia.
PubMed, Cochrane Library, Google Scholar, SCOPUS, Web of Science and PsycINFO, and article found in University online repository were accessed. Observational studies such as cross-sectional, case-control and prospective cohort reported using English language was involved. I2 statistic was used to check heterogeneity. Egger's test and funnel plot were used to measure publication bias. Weighted inverse variance random effects model was also performed.
Seven studies with 1,225 study participants were retrieved to estimate the pooled prevalence of adverse birth outcome and associated factors. The pooled prevalence of adverse birth outcome among diabetic pregnant women was 5.3% [95% CI; 1.61, 17.41]. Fasting blood glucose level above 100 mg/dl [Adjusted Odds ratio (AOR) = 10.51; 95% Confidence Interval (CI) = 5.90, 15.12], two hour post prandial glucose level above 120 mg/dl [AOR = 8.77; 95% CI = 4.51, 13.03], gestational age <37 completed week [AOR = 9.76; 95% CI = 5.29, 14.23], no ANC follow-up [AOR = 10.78; 95% CI = 6.12, 15.44], history of previous adverse outcomes [AOR = 3.47; 95% CI = 1.04, 5.90], maternal age < 30 years [AOR = 3.47; 95% CI = 1.04, 5.90], and illiteracy [AOR = 2.89; 95% CI = 0.81,4.97)] were associated factors of adverse birth outcome.
The pooled prevalence of adverse birth outcomes among diabetic pregnant women in Ethiopia was high. Child born from mothers who were illiterate, maternal age < 30 years, gestational age < 37 completed weeks, history of previous adverse birth outcomes and no ANC follow-up increased the risk of adverse birth outcome.
It is registered in PROSPERO data base: (PROSPERO 2020: CRD42020167734).
在埃塞俄比亚等中低收入国家，糖尿病孕妇的不良母婴结局发生率较高。为了制定、评估和改进有效的预防措施，需要有精确的流行病学证据。本系统评价和荟萃分析首次估计了埃塞俄比亚糖尿病孕妇不良母婴结局的综合发生率及相关因素。
检索了 PubMed、Cochrane 图书馆、Google Scholar、SCOPUS、Web of Science 和 PsycINFO，以及大学在线知识库中的文章。纳入了使用英语报告的观察性研究，如横断面研究、病例对照研究和前瞻性队列研究。使用 I2 统计量检查异质性。采用 Egger 检验和漏斗图来测量发表偏倚。还进行了加权逆方差随机效应模型分析。
共检索到 7 项研究，包含 1225 名研究参与者，用于估计不良母婴结局的综合发生率和相关因素。糖尿病孕妇不良母婴结局的综合发生率为 5.3%[95%置信区间：1.61，17.41]。空腹血糖水平高于 100mg/dl[调整后优势比（AOR）=10.51；95%置信区间（CI）=5.90，15.12]、餐后 2 小时血糖水平高于 120mg/dl[AOR=8.77；95%CI=4.51，13.03]、妊娠周龄<37 周[AOR=9.76；95%CI=5.29，14.23]、未进行 ANC 随访[AOR=10.78；95%CI=6.12，15.44]、有不良妊娠结局史[AOR=3.47；95%CI=1.04，5.90]、产妇年龄<30 岁[AOR=3.47；95%CI=1.04，5.90]和文盲[AOR=2.89；95%CI=0.81，4.97)]是不良母婴结局的相关因素。
埃塞俄比亚糖尿病孕妇的不良母婴结局发生率较高。母亲为文盲、产妇年龄<30 岁、妊娠周龄<37 周、有不良妊娠结局史和未进行 ANC 随访的儿童发生不良母婴结局的风险增加。
本研究已在 PROSPERO 数据库中注册（PROSPERO 2020: CRD42020167734）。
