Center for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, MN, USA; Center for Infectious Disease Research and Policy, C315 Mayo Memorial Building, MMC 263, 420 Delaware Street, SE, Minneapolis, MN 55455, USA.
Center for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, MN, USA.
Vaccine. 2021 Oct 29;39(45):6573-6584. doi: 10.1016/j.vaccine.2021.08.010. Epub 2021 Sep 30.
Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to ensure a rapid and effective public-health response to future influenza pandemics. The Influenza Vaccines Research and Development (R&D) Roadmap (IVR) was created, through an extensive international stakeholder engagement process, to promote influenza vaccine R&D. The roadmap covers a 10-year timeframe and is organized into six sections: virology; immunology; vaccinology for seasonal influenza vaccines; vaccinology for universal influenza vaccines; animal and human influenza virus infection models; and policy, finance, and regulation. Each section identifies barriers, gaps, strategic goals, milestones, and additional R&D priorities germane to that area. The roadmap includes 113 specific R&D milestones, 37 of which have been designated high priority by the IVR expert taskforce. This report summarizes the major issues and priority areas of research outlined in the IVR. By identifying the key issues and steps to address them, the roadmap not only encourages research aimed at new solutions, but also provides guidance on the use of innovative tools to drive breakthroughs in influenza vaccine R&D.
急需改进的流感疫苗，以减轻季节性流感的负担，并确保对未来流感大流行做出快速有效的公共卫生反应。通过广泛的国际利益相关者参与过程，创建了流感疫苗研发（R&D）路线图（IVR），以促进流感疫苗研发。该路线图涵盖了 10 年的时间框架，分为六个部分：病毒学；免疫学；季节性流感疫苗的疫苗学；通用流感疫苗的疫苗学；动物和人类流感病毒感染模型；以及政策、金融和监管。每个部分都确定了与该领域相关的障碍、差距、战略目标、里程碑和其他研发重点。该路线图包括 113 个具体的研发里程碑，其中 37 个已被 IVR 专家工作组指定为高度优先事项。本报告总结了 IVR 中概述的主要问题和优先研究领域。通过确定关键问题和解决问题的步骤，路线图不仅鼓励针对新解决方案的研究，还为利用创新工具推动流感疫苗研发突破提供了指导。
