Department of Endocrinology and Metabolism, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Endocrinol (Lausanne). 2021 Sep 16;12:730279. doi: 10.3389/fendo.2021.730279. eCollection 2021.
Thyroid nodules (TNs) are a common thyroid disorder that can be caused by many factors. Several studies have investigated the relationship between TNs and metabolic syndrome (MetS), but the role of sex and age remains controversial. The purpose of this paper was to analyze published data from all relevant studies to reliably estimate the relationship between TNs and MetS.
Thirteen articles were included in this study; articles were identified by searching for publications until July 2021 in PubMed, EMBASE, the Cochrane Library and the Web of Science. The outcomes are presented as the summary odds ratio (OR) and 95% confidence interval (CI) and the pooled prevalence and 95% CI.
The TNs prevalence was significantly higher in MetS patients than in controls (OR 1.88, 95% CI 1.42-2.50, P < 0.0001) and was independent of sex (male: OR 1.53, 95% CI 1.20-1.94, P = 0.0006; female: OR 1.90, 95% CI 1.54-2.33, P < 0.00001; combined: OR 2.06, 95% CI 1.31-3.25, P = 0.002) and age (< 40 years old: OR 1.62, 95% CI 1.39-1.89, P < 0.0001; 4050 years old: OR 2.14, 95% CI 1.49-3.08, P < 0.0001;5060 years old: OR 1.50, 95% CI 1.08-2.07, P = 0. 01; 60 years old: OR 1.70, 95% CI 1.36-2.14, P < 0.00001); the pooled TNs prevalence in MetS patients was 45% (95% CI 36-54%). However, it has not yet been considered that MetS is related to TNs in people with iodine deficiency (OR 3.14, 95% CI 0.92-10.73, P = 0.07).
The meta-analysis results showed a strong correlation between TNs and MetS. Both male and female patients with MetS had an increased TNs prevalence. In addition, the prevalence was independent of age. However, MetS is not considered to be associated with TNs in iodine-deficient populations.
甲状腺结节（TNs）是一种常见的甲状腺疾病，可能由多种因素引起。几项研究已经探讨了 TNs 与代谢综合征（MetS）之间的关系，但性别和年龄的作用仍存在争议。本研究的目的是分析所有相关研究的已发表数据，以可靠地评估 TNs 与 MetS 之间的关系。
通过在 PubMed、EMBASE、Cochrane 图书馆和 Web of Science 中搜索截至 2021 年 7 月的出版物，共纳入 13 篇文章。研究结果以汇总优势比（OR）和 95%置信区间（CI）以及汇总患病率和 95%CI 表示。
与对照组相比，MetS 患者的 TNs 患病率明显更高（OR 1.88，95%CI 1.42-2.50，P<0.0001），且与性别无关（男性：OR 1.53，95%CI 1.20-1.94，P=0.0006；女性：OR 1.90，95%CI 1.54-2.33，P<0.00001；合并：OR 2.06，95%CI 1.31-3.25，P=0.002）和年龄（<40 岁：OR 1.62，95%CI 1.39-1.89，P<0.0001；4050 岁：OR 2.14，95%CI 1.49-3.08，P<0.0001；5060 岁：OR 1.50，95%CI 1.08-2.07，P=0.01；60 岁以上：OR 1.70，95%CI 1.36-2.14，P<0.00001）；MetS 患者中 TNs 的总体患病率为 45%（95%CI 36-54%）。然而，尚未考虑到碘缺乏人群中 MetS 与 TNs 之间的关系（OR 3.14，95%CI 0.92-10.73，P=0.07）。
荟萃分析结果表明 TNs 与 MetS 之间存在很强的相关性。患有 MetS 的男性和女性患者均有更高的 TNs 患病率。此外，这种患病率与年龄无关。然而，在碘缺乏人群中，并未发现 MetS 与 TNs 之间存在关联。
