Department of Clinical Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
Med Sci Monit. 2021 Feb 1;27:e927935. doi: 10.12659/MSM.927935.
BACKGROUND Thyroid nodules (TNs) and metabolic syndrome (MS) have been individually associated with colorectal polyps. However, the potential joint relationship between them in relation to colorectal polyps has not been fully evaluated. This study aimed to validate the association of TNs/MS and colorectal polyps/adenomas and to determine the risk of colonic polyps in patients with TNs/MS. MATERIAL AND METHODS A retrospective study was conducted on patients undergoing routine health checks in the First Affiliated Hospital of Wenzhou Medical University from July 2014 to August 2017. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for colorectal polyps/adenomas after adjusting for confounding factors. Then patients were divided into 4 groups according to whether they had TNs or MS. Relative excess risks of interaction, attributable proportion, and synergy index were used to determine the additive interaction of TNs and MS on colorectal polyps/adenomas. RESULTS A total of 4514 eligible patients were included in this study. TNs and MS were confirmed to be independent risk factors for colorectal polyps/adenomas. Compared with the group of TNs(-)/MS(-), the odds ratios of TNs(+)/MS(+) in colorectal polyps (odds ratio [OR]: 3.031, 95% confidence interval [CI]: 2.262-4.062, P<0.05) or adenomas (OR: 2.894, 95% CI: 2.099-3.990, P<0.05) were significantly increased, and there was an interactive additive effect between TNs and MS. CONCLUSIONS TNs and MS have an associative and superimposing effect on the increased occurrence of colorectal adenomas. Colonoscopy screening should be advocated for patients with both of these diseases.
甲状腺结节（TNs）和代谢综合征（MS）已分别与结直肠息肉相关。然而，它们之间潜在的联合关系与结直肠息肉的关系尚未得到充分评估。本研究旨在验证 TNs/MS 与结直肠息肉/腺瘤的关联，并确定患有 TNs/MS 的患者发生结肠息肉的风险。
对 2014 年 7 月至 2017 年 8 月在温州医科大学第一附属医院进行常规健康检查的患者进行回顾性研究。采用单因素和多因素 logistic 回归分析，在调整混杂因素后，确定结直肠息肉/腺瘤的独立危险因素。然后根据患者是否存在 TNs 或 MS 将其分为 4 组。相对超额风险交互作用、归因比例和协同指数用于确定 TNs 和 MS 对结直肠息肉/腺瘤的相加交互作用。
本研究共纳入 4514 例符合条件的患者。TNs 和 MS 被证实是结直肠息肉/腺瘤的独立危险因素。与 TNs(-)/MS(-)组相比，TNs(+)/MS(+)组发生结直肠息肉（比值比[OR]：3.031，95%置信区间[CI]：2.262-4.062，P<0.05）或腺瘤（OR：2.894，95% CI：2.099-3.990，P<0.05）的比值比显著增加，且 TNs 和 MS 之间存在交互相加作用。
TNs 和 MS 对结直肠腺瘤发生率的增加具有关联和叠加作用。对于同时患有这两种疾病的患者，应提倡进行结肠镜筛查。
