Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Front Immunol. 2021 Sep 17;12:737406. doi: 10.3389/fimmu.2021.737406. eCollection 2021.
IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 in diagnosis, prognosis and treatment of COVID-19 patients. We also summarize a promising role of IL-7 as a vaccine adjuvant. It could potentially enhance the immune responses to vaccines especially against SARS-CoV-2 or other new vaccines.
IL-7/IL-7R 信号对于胸腺和外周血中许多淋巴细胞的发育、成熟、维持和存活至关重要。IL-7 已被用于临床前和临床研究中的免疫疗法，以治疗癌症、HIV 感染和败血症。在这里，我们讨论了 IL-7 在 COVID-19 患者的诊断、预后和治疗中的关键作用。我们还总结了 IL-7 作为疫苗佐剂的有希望的作用。它可能增强对疫苗的免疫反应，特别是针对 SARS-CoV-2 或其他新疫苗。
Zotero 插件