• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

lncRNA-MALAT1和MicroRNA-146a甲基化状态对慢性阻塞性肺疾病患者肺功能及COX2表达水平的影响

Effect of Methylation Status of lncRNA-MALAT1 and MicroRNA-146a on Pulmonary Function and Expression Level of COX2 in Patients With Chronic Obstructive Pulmonary Disease.

作者信息

Sun Li, Xu Aiqun, Li Min, Xia Xingyuan, Li Pulin, Han Rui, Fei Guanghe, Zhou Sijing, Wang Ran

机构信息

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Department of General Medicine, Hefei Second People's Hospital, Hefei, China.

出版信息

Front Cell Dev Biol. 2021 Sep 8;9:667624. doi: 10.3389/fcell.2021.667624. eCollection 2021.

DOI:10.3389/fcell.2021.667624
PMID:34604205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8479795/
Abstract

This study aimed to investigate the role of methylation of MALAT1 and miR-146a in the pathogenesis of chronic obstructive pulmonary disease (COPD). COPD patients were grouped according to their methylation status of MALAT1 and miR-146a promoters, and we found that forced vital capacity, volume that has been exhaled at the end of the first second of forced expiration, and diffusion capacity for carbon monoxide were the highest in the MALAT1 HYPO + miR-146a HYPER group and lowest in the MALAT1 HYPER + miR-146a HYPO group, and COPD patients with hypermethylated MALAT1 showed lower expression of MALAT1 than that in the COPD patients with hypomethylated MALAT1. Meanwhile, miR-146a was the most significantly upregulated in the MALAT1 HYPER + miR-146a HYPO group and the most significantly downregulated in the MALAT1 HYPO + miR-146a HYPER group. Both prostaglandin E and cyclooxygenase 2 (COX2) expression were the highest in the MALAT1 HYPO + miR-146a HYPER group and the lowest in the MALAT1 HYPER + miR-146a HYPO group. In conclusion, our results established a MALAT1/miR-146a/COX2 signaling axis. The overexpression of MALAT1 could increase the expression of COX2 by inhibiting the expression of miR-146a, thus affecting the pulmonary function of COPD patients.

摘要

本研究旨在探讨MALAT1和miR-146a甲基化在慢性阻塞性肺疾病（COPD）发病机制中的作用。根据MALAT1和miR-146a启动子的甲基化状态对COPD患者进行分组，我们发现，MALAT1低甲基化+miR-146a高甲基化组的用力肺活量、第1秒用力呼气末呼出量和一氧化碳弥散量最高，而MALAT1高甲基化+miR-146a低甲基化组最低，且MALAT1高甲基化的COPD患者中MALAT1的表达低于MALAT1低甲基化的COPD患者。同时，miR-146a在MALAT1高甲基化+miR-146a低甲基化组中上调最为显著，而在MALAT1低甲基化+miR-146a高甲基化组中下调最为显著。前列腺素E和环氧化酶2（COX2）的表达均在MALAT1低甲基化+miR-146a高甲基化组中最高，而在MALAT1高甲基化+miR-146a低甲基化组中最低。总之，我们的结果建立了一个MALAT1/miR-146a/COX2信号轴。MALAT1的过表达可通过抑制miR-146a的表达来增加COX2的表达，从而影响COPD患者的肺功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/a27043494885/fcell-09-667624-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/9ba4f9530c99/fcell-09-667624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/0f953e452e47/fcell-09-667624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/240dc0ce63cd/fcell-09-667624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/f84ff6ee19bd/fcell-09-667624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/35ae57787095/fcell-09-667624-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/ff2fe63179b2/fcell-09-667624-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/b1a3d3fbe8df/fcell-09-667624-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/a27043494885/fcell-09-667624-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/9ba4f9530c99/fcell-09-667624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/0f953e452e47/fcell-09-667624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/240dc0ce63cd/fcell-09-667624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/f84ff6ee19bd/fcell-09-667624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/35ae57787095/fcell-09-667624-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/ff2fe63179b2/fcell-09-667624-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/b1a3d3fbe8df/fcell-09-667624-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f3/8479795/a27043494885/fcell-09-667624-g008.jpg

相似文献

1
Effect of Methylation Status of lncRNA-MALAT1 and MicroRNA-146a on Pulmonary Function and Expression Level of COX2 in Patients With Chronic Obstructive Pulmonary Disease.lncRNA-MALAT1和MicroRNA-146a甲基化状态对慢性阻塞性肺疾病患者肺功能及COX2表达水平的影响
Front Cell Dev Biol. 2021 Sep 8;9:667624. doi: 10.3389/fcell.2021.667624. eCollection 2021.
2
The clinical value of lncRNA MALAT1 and its targets miR-125b, miR-133, miR-146a, and miR-203 for predicting disease progression in chronic obstructive pulmonary disease patients.长链非编码 RNA MALAT1 及其靶基因 miR-125b、miR-133、miR-146a 和 miR-203 对预测慢性阻塞性肺疾病患者疾病进展的临床价值。
J Clin Lab Anal. 2020 Sep;34(9):e23410. doi: 10.1002/jcla.23410. Epub 2020 Jun 25.
3
Combined Effects of PVT1 and MiR-146a Single Nucleotide Polymorphism on the Lung Function of Smokers with Chronic Obstructive Pulmonary Disease.PVT1 与 miR-146a 单核苷酸多态性对吸烟慢性阻塞性肺疾病患者肺功能的联合影响。
Int J Biol Sci. 2018 Jun 23;14(10):1153-1162. doi: 10.7150/ijbs.25420. eCollection 2018.
4
Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.miR-146a单核苷酸多态性对慢性阻塞性肺疾病吸烟者COX-2蛋白表达及肺功能的影响
Int J Chron Obstruct Pulmon Dis. 2015 Mar 4;10:463-73. doi: 10.2147/COPD.S74345. eCollection 2015.
5
LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis.长链非编码 RNA MALAT1 通过靶向 miR-146a-PI3K/Akt/mTOR 轴来介导 LPS 处理的关节软骨细胞的增殖。
Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
6
Long non-coding RNA PVT1, a novel biomarker for chronic obstructive pulmonary disease progression surveillance and acute exacerbation prediction potentially through interaction with microRNA-146a.长链非编码RNA PVT1，一种可能通过与微小RNA-146a相互作用来监测慢性阻塞性肺疾病进展和预测急性加重的新型生物标志物。
J Clin Lab Anal. 2020 Aug;34(8):e23346. doi: 10.1002/jcla.23346. Epub 2020 Apr 27.
7
Knockdown of LncRNA MALAT1 contributes to the suppression of inflammatory responses by up-regulating miR-146a in LPS-induced acute lung injury.敲低长链非编码 RNA MALAT1 通过上调 LPS 诱导的急性肺损伤中的 miR-146a 来抑制炎症反应。
Connect Tissue Res. 2018 Nov;59(6):581-592. doi: 10.1080/03008207.2018.1439480. Epub 2018 Apr 13.
8
PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis.PVT1(rs13281615)和 miR-146a(rs2910164)多态性通过调节 COX2 表达和细胞凋亡影响结肠癌的预后。
J Cell Physiol. 2019 Aug;234(10):17538-17548. doi: 10.1002/jcp.28377. Epub 2019 Feb 28.
9
Long non-coding RNA MALAT1 modulate cell migration, proliferation and apoptosis by sponging microRNA-146a to regulate CXCR4 expression in acute myeloid leukemia.长链非编码 RNA MALAT1 通过海绵吸附 microRNA-146a 调节 CXCR4 表达来调节急性髓系白血病中的细胞迁移、增殖和凋亡。
Hematology. 2021 Dec;26(1):43-52. doi: 10.1080/16078454.2020.1867781.
10
[LncRNA Modulates the Immunoreaction of Rats with Lipopolysaccharide-induced Sepsis by Targeting the miR-146a/NF-κB P65 Pathway].[长链非编码RNA通过靶向miR-146a/NF-κB P65通路调节脂多糖诱导的脓毒症大鼠的免疫反应]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):865-870.

引用本文的文献

1
Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progression.解析 COPD 中的长链非编码 RNA：揭示其在预后和诊断中的潜力及其在肺癌进展中的驱动作用。
Int J Mol Sci. 2024 Aug 19;25(16):9001. doi: 10.3390/ijms25169001.
2
LncRNA MIR210HG promotes phenotype switching of pulmonary arterial smooth muscle cells through autophagy-dependent ferroptosis pathway.长链非编码 RNA MIR210HG 通过自噬依赖性铁死亡途径促进肺动脉平滑肌细胞表型转换。
Apoptosis. 2024 Oct;29(9-10):1648-1662. doi: 10.1007/s10495-024-01963-4. Epub 2024 Apr 18.
3
Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer.

本文引用的文献

1
Statins in High-Risk Chronic Obstructive Pulmonary Disease Outpatients: No Impact on Time to First Exacerbation and All-Cause Mortality - The STATUETTE Cohort Study.高风险慢性阻塞性肺疾病门诊患者中的他汀类药物：对首次加重时间和全因死亡率无影响 - STATUETTE 队列研究。
Int J Chron Obstruct Pulmon Dis. 2021 Mar 5;16:579-589. doi: 10.2147/COPD.S296472. eCollection 2021.
2
Microbiota Imbalance Contributes to COPD Deterioration by Enhancing IL-17a Production via miR-122 and miR-30a.微生物群失衡通过miR-122和miR-30a增强IL-17a的产生，从而导致慢性阻塞性肺疾病（COPD）恶化。
Mol Ther Nucleic Acids. 2020 Sep 23;22:520-529. doi: 10.1016/j.omtn.2020.09.017. eCollection 2020 Dec 4.
3
导致 COPD 和肺癌合并症的机制。
Int J Mol Sci. 2023 Feb 2;24(3):2859. doi: 10.3390/ijms24032859.
4
Mechanistic studies of MALAT1 in respiratory diseases.MALAT1在呼吸系统疾病中的机制研究。
Front Mol Biosci. 2022 Nov 7;9:1031861. doi: 10.3389/fmolb.2022.1031861. eCollection 2022.
5
Focus on long non-coding RNA MALAT1: Insights into acute and chronic lung diseases.聚焦长链非编码RNA MALAT1：对急慢性肺部疾病的见解
Front Genet. 2022 Sep 16;13:1003964. doi: 10.3389/fgene.2022.1003964. eCollection 2022.
6
Identification of Ferroptosis-Related Hub Genes and Their Association with Immune Infiltration in Chronic Obstructive Pulmonary Disease by Bioinformatics Analysis.基于生物信息学分析鉴定慢性阻塞性肺疾病中与铁死亡相关的枢纽基因及其与免疫浸润的关系。
Int J Chron Obstruct Pulmon Dis. 2022 May 24;17:1219-1236. doi: 10.2147/COPD.S348569. eCollection 2022.
7
Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.外核体诱导肿瘤发生中的表观遗传调控：ncRNAs 的新作用。
Biomolecules. 2022 Mar 28;12(4):513. doi: 10.3390/biom12040513.
Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. The 2020 GOLD Science Committee Report on COVID-19 and Chronic Obstructive Pulmonary Disease.
全球慢性阻塞性肺疾病诊断、管理和预防倡议。2020 年 GOLD 科学委员会关于 COVID-19 和慢性阻塞性肺疾病的报告。
Am J Respir Crit Care Med. 2021 Jan 1;203(1):24-36. doi: 10.1164/rccm.202009-3533SO.
4
High expression of long non-coding RNA MALAT1 correlates with raised acute respiratory distress syndrome risk, disease severity, and increased mortality in sepstic patients.长链非编码RNA MALAT1的高表达与脓毒症患者急性呼吸窘迫综合征风险增加、疾病严重程度及死亡率升高相关。
Int J Clin Exp Pathol. 2019 May 1;12(5):1877-1887. eCollection 2019.
5
Circular RNA hsa_circ_0016070 Is Associated with Pulmonary Arterial Hypertension by Promoting PASMC Proliferation.环状RNA hsa_circ_0016070通过促进肺动脉平滑肌细胞增殖与肺动脉高压相关。
Mol Ther Nucleic Acids. 2019 Dec 6;18:275-284. doi: 10.1016/j.omtn.2019.08.026. Epub 2019 Sep 9.
6
Estrogen administration reduces the risk of pulmonary arterial hypertension by modulating the miR-133a signaling pathways in rats.雌激素通过调节大鼠 miR-133a 信号通路降低肺动脉高压的风险。
Gene Ther. 2020 Apr;27(3-4):113-126. doi: 10.1038/s41434-019-0103-6. Epub 2019 Sep 27.
7
LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis.长链非编码 RNA MALAT1 通过靶向 miR-146a-PI3K/Akt/mTOR 轴来介导 LPS 处理的关节软骨细胞的增殖。
Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
8
MALAT1-Driven Inhibition of Wnt Signal Impedes Proliferation and Inflammation in Fibroblast-Like Synoviocytes Through CTNNB1 Promoter Methylation in Rheumatoid Arthritis.MALAT1 驱动的 Wnt 信号抑制通过 CTNNB1 启动子甲基化阻碍类风湿关节炎成纤维样滑膜细胞的增殖和炎症。
Hum Gene Ther. 2019 Aug;30(8):1008-1022. doi: 10.1089/hum.2018.212. Epub 2019 Jun 26.
9
Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies.慢性阻塞性肺疾病（COPD）代谢综合征（MetS）的病理生物学机制：临床意义和治疗策略。
Pharmacol Ther. 2019 Jun;198:160-188. doi: 10.1016/j.pharmthera.2019.02.013. Epub 2019 Feb 26.
10
Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin.确定H19-miR-675-3p-IGF1R和H19-miR-200a-PDCD4在褪黑素治疗肺动脉高压中的作用。
Mol Ther Nucleic Acids. 2018 Dec 7;13:44-54. doi: 10.1016/j.omtn.2018.08.015. Epub 2018 Aug 24.