锌补充剂对肺结核患者血清生化参数影响的研究：一项双盲安慰剂对照试验。
Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial.
作者信息
Zolfaghari Bahareh, Ghanbari Mahboobeh, Musavi Hadis, Bavandpour Baghshahi Parizad, Taghikhani Mohammad, Pourfallah Fatemeh
机构信息
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Clinical Biochemistry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Rep Biochem Mol Biol. 2021 Jul;10(2):173-182. doi: 10.52547/rbmb.10.2.173.
BACKGROUND
Zinc (Zn) is nutritionally essential trace element, and thus deficiency may severely affect human health. The results of cross-sectional studies indicate that micronutrient deficiencies are common in patients with tuberculosis. Our goal is to investigate whether Zn supplementation can increase the effects of anti-TB treatment or not.
METHODS
Patients with newly diagnosed tuberculosis were divided in to 2 groups. One group (n= 37) received capsule contains 50 mg of elemental zinc (as zinc sulfate) for 6 months every other day (micronutrient group) and Group II (n= 37) received placebo. Both groups received the same anti-tuberculosis treatment recommended by the WHO. Clinical examination, BMI, chest X-ray, direct sputum examination, assessment of serum zinc levels (by atomic absorption spectrophotometry), and biochemical markers serum concentration (by using an RA1000 AutoAnalyzer) were carried out before and after 2- and 6-months anti-tuberculosis treatment.
RESULTS
Plasma zinc concentrations in the micronutrient group was higher than placebo group After treatment. In the placebo group increasing in SGOT and SGPT concentrations were significantly higher than micronutrient group after 2 months of treatment (p< 0.05). The significant changes (p< 0.05) were observed on the serum levels of total protein, albumin. Alkaline phosphatase (ALP) levels, serum creatinine, uric acid and urea in groups were not significantly different.
CONCLUSION
Zinc supplementation results in earlier sputum smear conversion in the micronutrient group during the first 6 weeks. Increased body weight and serum zinc and serum albumin and decrease in total protein was observed in the micronutrient group.
背景
锌（Zn）是一种营养必需的微量元素，因此缺乏可能会严重影响人类健康。横断面研究结果表明，微量营养素缺乏在结核病患者中很常见。我们的目标是研究补充锌是否能增强抗结核治疗的效果。
方法
将新诊断的结核病患者分为两组。一组（n = 37）每隔一天服用含50毫克元素锌（硫酸锌形式）的胶囊，持续6个月（微量营养素组），第二组（n = 37）服用安慰剂。两组均接受世界卫生组织推荐的相同抗结核治疗。在抗结核治疗2个月和6个月前后，进行临床检查、体重指数、胸部X光、直接痰涂片检查、血清锌水平评估（采用原子吸收分光光度法）以及生化标志物血清浓度测定（使用RA1000自动分析仪）。
结果
治疗后，微量营养素组的血浆锌浓度高于安慰剂组。治疗2个月后，安慰剂组血清谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）浓度的升高显著高于微量营养素组（p < 0.05）。两组总蛋白、白蛋白血清水平有显著变化（p < 0.05）。两组碱性磷酸酶（ALP）水平、血清肌酐、尿酸和尿素无显著差异。
结论
补充锌使微量营养素组在最初6周内痰涂片转阴更早。微量营养素组体重增加，血清锌和血清白蛋白升高，总蛋白降低。
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