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Neutrophil-rich, noncollagenous 16A domain-negative bullous pemphigoid associated with psoriasis.

作者信息

Sussman Morgan E, Grossman Shoshana K, Hsu Sylvia, Lee Jason B, Motaparthi Kiran

机构信息

Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

出版信息

JAAD Case Rep. 2021 Sep 1;16:137-140. doi: 10.1016/j.jdcr.2021.08.025. eCollection 2021 Oct.

DOI:10.1016/j.jdcr.2021.08.025
PMID:34604489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8463795/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/f765de17e172/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/dd339c8830b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/08ed69d4cbe9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/f8e8abf0a326/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/f765de17e172/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/dd339c8830b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/08ed69d4cbe9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/f8e8abf0a326/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591b/8463795/f765de17e172/gr4.jpg

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Neutrophil-rich, noncollagenous 16A domain-negative bullous pemphigoid associated with psoriasis.与银屑病相关的富含中性粒细胞、非胶原蛋白16A结构域阴性的大疱性类天疱疮。
JAAD Case Rep. 2021 Sep 1;16:137-140. doi: 10.1016/j.jdcr.2021.08.025. eCollection 2021 Oct.
2
Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies.在大疱性类天疱疮患者的外周血中可检测到对180 kDa大疱性类天疱疮自身抗原的NC16A结构域具有特异性的记忆B细胞，并可在体外诱导其合成自身抗体。
J Invest Dermatol. 2003 Mar;120(3):372-8. doi: 10.1046/j.1523-1747.2003.12071.x.
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Clinical and Immunological Profiles of 14 Patients With Bullous Pemphigoid Without IgG Autoantibodies to the BP180 NC16A Domain.14 例无 IgG 自身抗体针对 BP180 NC16A 域的大疱性类天疱疮患者的临床和免疫学特征。
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A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid.一种用于检测大疱性类天疱疮患者循环抗BP180自身抗体的高度灵敏的酶联免疫吸附测定法。
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Normal human skin is superior to monkey oesophagus substrate for detection of circulating BP180-NC16A-specific IgG antibodies in bullous pemphigoid.正常人体皮肤优于猴食道底物，用于检测大疱性类天疱疮患者循环 BP180-NC16A 特异性 IgG 抗体。
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Int J Mol Sci. 2025 Jan 17;26(2):749. doi: 10.3390/ijms26020749.
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The Intriguing Links between Psoriasis and Bullous Pemphigoid.银屑病与大疱性类天疱疮之间的有趣联系。
J Clin Med. 2022 Dec 31;12(1):328. doi: 10.3390/jcm12010328.

本文引用的文献

1
Psoriasis Flares Following Systemic Glucocorticoid Exposure in Patients With a History of Psoriasis.银屑病患者在有银屑病病史的情况下接受全身糖皮质激素治疗后出现病情发作。
JAMA Dermatol. 2021 Feb 1;157(2):198-201. doi: 10.1001/jamadermatol.2020.4219.
2
Patients with bullous pemphigoid and comorbid psoriasis present with less blisters and lower serum levels of anti-BP180 autoantibodies.患有大疱性类天疱疮和合并银屑病的患者水疱较少，血清中抗 BP180 自身抗体水平较低。
J Eur Acad Dermatol Venereol. 2021 Apr;35(4):981-987. doi: 10.1111/jdv.17013. Epub 2020 Nov 17.
3
Bullous pemphigoid associated with psoriasis showing marked neutrophilic infiltrates.
J Dtsch Dermatol Ges. 2021 Jan;19(1):105-108. doi: 10.1111/ddg.14166. Epub 2020 Jul 14.
4
False-Negative Rate of Direct Immunofluorescence on Lower Extremities in Bullous Pemphigoid.大疱性类天疱疮下肢直接免疫荧光的假阴性率
Am J Dermatopathol. 2021 Jan 1;43(1):42-44. doi: 10.1097/DAD.0000000000001710.
5
Neutrophil-predominant bullous pemphigoid induced by checkpoint inhibitors: A case series.中性粒细胞为主型大疱性类天疱疮：病例系列。
J Cutan Pathol. 2020 Aug;47(8):742-746. doi: 10.1111/cup.13687. Epub 2020 Apr 29.
6
Methotrexate is safe and efficient as long-term treatment for bullous pemphigoid.甲氨蝶呤作为大疱性类天疱疮的长期治疗药物是安全有效的。
Eur J Dermatol. 2019 Apr 1;29(2):217-218. doi: 10.1684/ejd.2019.3501.
7
Secukinumab decreased circulating anti-BP180-NC16a autoantibodies in a patient with coexisting psoriasis vulgaris and bullous pemphigoid.司库奇尤单抗降低了一名同时患有寻常型银屑病和大疱性类天疱疮患者循环中的抗BP180-NC16a自身抗体水平。
J Dermatol. 2019 Jun;46(6):e216-e217. doi: 10.1111/1346-8138.14760. Epub 2019 Jan 10.
8
Interaction of Psoriasis and Bullous Diseases.银屑病与大疱性疾病的相互作用
Front Med (Lausanne). 2018 Aug 8;5:222. doi: 10.3389/fmed.2018.00222. eCollection 2018.
9
Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia.沙特阿拉伯一家三级医院自身免疫性表皮下大疱病中细胞浸润的组织学特征
Clin Cosmet Investig Dermatol. 2018 Apr 24;11:187-194. doi: 10.2147/CCID.S158388. eCollection 2018.
10
Humoral Epitope Spreading in Autoimmune Bullous Diseases.自身免疫性大疱性疾病中的体液性表位扩散。
Front Immunol. 2018 Apr 17;9:779. doi: 10.3389/fimmu.2018.00779. eCollection 2018.