沙特阿拉伯一家三级医院自身免疫性表皮下大疱病中细胞浸润的组织学特征
Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia.
作者信息
BinJadeed Hessah F, Alyousef Alanoud M, Alsaif Fahad M, Alhumidi Ahmed A, Alotaibi Homaid O
机构信息
College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Clin Cosmet Investig Dermatol. 2018 Apr 24;11:187-194. doi: 10.2147/CCID.S158388. eCollection 2018.
BACKGROUND
Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses.
MATERIALS AND METHODS
This retrospective analysis was conducted at a hospital in Riyadh, Saudi Arabia using biopsy-based data collected from 65 patients.
RESULTS
Spongiotic changes, neutrophils, and lymphocyte infiltrations in the epidermis differed among the subepidermal bullous diseases. The DEJ showed a difference in the extent of neutrophil infiltration. The dermis showed differences in perivascular lymphocytic infiltration, neutrophilic infiltration, eosinophilic infiltration, and dermal edema.
CONCLUSION
The dermal and DEJ showed most of the histopathologic changes in subepidermal autoimmune bullous dermatoses.
背景
自身免疫性表皮下大疱性皮肤病具有与一系列位于真皮表皮交界处（DEJ）的免疫反应物相似的临床特征。由于其临床表现相似，若无免疫荧光检测则难以获得精确诊断。本研究的目的是描述自身免疫性表皮下大疱性皮肤病中的细胞性皮肤浸润情况。
材料与方法
本回顾性分析在沙特阿拉伯利雅得的一家医院进行，使用从65例患者收集的基于活检的数据。
结果
表皮下大疱性疾病之间，表皮的海绵状改变、中性粒细胞和淋巴细胞浸润存在差异。DEJ在中性粒细胞浸润程度上存在差异。真皮在血管周围淋巴细胞浸润、嗜中性粒细胞浸润、嗜酸性粒细胞浸润和真皮水肿方面存在差异。
结论
真皮和DEJ显示出表皮下自身免疫性大疱性皮肤病的大部分组织病理学变化。
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