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与年龄相关的风险因素与 SARS-CoV-2 感染的严重程度：系统评价和荟萃分析。

Age-related risk factors and severity of SARS-CoV-2 infection: a systematic review and meta-analysis.

机构信息

Biomedical Research Foundation, Dhaka, Bangladesh.

Department of Biotechnology, BRAC University, Dhaka, Bangladesh.

出版信息

J Prev Med Hyg. 2021 Jul 30;62(2):E329-E371. doi: 10.15167/2421-4248/jpmh2021.62.2.1946. eCollection 2021 Jun.

DOI:10.15167/2421-4248/jpmh2021.62.2.1946
PMID:34604574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8451365/
Abstract

OBJECTIVES

We aimed to estimate the prevalence of reported symptoms and comorbidities, and investigate the factors associated with age of the SARS-CoV-2 infected patients.

METHODS

We performed a systematic review with meta-analysis (PROSPERO registration: CRD42020182677) where the databases (PubMed, SCOPUS, EMBASE, WHO, Semantic Scholar, and COVID-19 Primer) were searched for clinical studies published from January to April, 2020. Initially, the pooled prevalence of symptoms and comorbidity of COVID-19 patients were estimated using random effect model and the age -related factors were identified performing multivariate analysis [factor analysis].

RESULTS

Twenty-nine articles with 4,884 COVID-19 patients were included in this study. Altogether, we found 33 symptoms and 44 comorbidities where the most frequent 19 symptoms and 11 comorbidities were included in the meta-analysis. The fever (84%), cough/dry cough (61%), and fatigue/weakness (42%) were found more prevalent while acute respiratory distress syndrome, hypertension and diabetes were the most prevalent comorbid condition. The factor analysis showed positive association between a cluster of symptoms and comorbidities with patients' age. The symptoms comprising fever, dyspnea/shortness of breath, nausea, vomiting, abdominal pain, dizziness, anorexia and pharyngalgia; and the comorbidities including diabetes, hypertension, coronary heart disease, COPD/lung disease and ARDS were the factors positively associated with COVID-19 patient's age.

CONCLUSION

As an unique effort, this study found a group of symptoms (fever, dyspnea/shortness of breath, nausea, vomiting, abdominal pain, dizziness, anorexia and pharyngalgia) and comorbidities (diabetes, hypertension, coronary heart disease, COPD/lung disease and ARDS), associated with the age of COVID-19 infected patients.

摘要

目的

我们旨在估计报告症状和合并症的患病率，并调查与 SARS-CoV-2 感染患者年龄相关的因素。

方法

我们进行了一项系统评价和荟萃分析（PROSPERO 注册：CRD42020182677），其中数据库（PubMed、SCOPUS、EMBASE、世界卫生组织、语义学者和 COVID-19 Primer）搜索了 2020 年 1 月至 4 月发表的临床研究。最初，使用随机效应模型估计 COVID-19 患者症状和合并症的合并患病率，并通过多元分析[因子分析]确定与年龄相关的因素。

结果

这项研究纳入了 29 篇文章和 4884 例 COVID-19 患者。我们总共发现了 33 种症状和 44 种合并症，其中最常见的 19 种症状和 11 种合并症被纳入荟萃分析。发热（84%）、咳嗽/干咳（61%）和乏力/虚弱（42%）更为常见，而急性呼吸窘迫综合征、高血压和糖尿病是最常见的合并症。因子分析显示，一组症状和合并症与患者年龄呈正相关。包括发热、呼吸困难/呼吸急促、恶心、呕吐、腹痛、头晕、厌食和咽痛在内的症状；以及包括糖尿病、高血压、冠心病、COPD/肺部疾病和 ARDS 在内的合并症是与 COVID-19 患者年龄呈正相关的因素。

结论

作为一项独特的努力，本研究发现了一组与 COVID-19 感染患者年龄相关的症状（发热、呼吸困难/呼吸急促、恶心、呕吐、腹痛、头晕、厌食和咽痛）和合并症（糖尿病、高血压、冠心病、COPD/肺部疾病和 ARDS）。

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4
Frailty indexed classification of Bangladeshi older adults' physio-psychosocial health and associated risk factors- a cross-sectional survey study.孟加拉国老年人生理心理社会健康及相关风险因素的衰弱指数分类-一项横断面调查研究。
BMC Geriatr. 2021 Jan 6;21(1):3. doi: 10.1186/s12877-020-01970-5.
5
Comorbidity and its Impact on Patients with COVID-19.合并症及其对COVID-19患者的影响。
SN Compr Clin Med. 2020;2(8):1069-1076. doi: 10.1007/s42399-020-00363-4. Epub 2020 Jun 25.
6
Prevalence of Comorbidities in COVID-19 Patients: A Systematic Review and Meta-Analysis.COVID-19患者合并症的患病率：一项系统评价和荟萃分析。
Arch Bone Jt Surg. 2020 Apr;8(Suppl 1):247-255. doi: 10.22038/abjs.2020.47754.2346.
7
Hypertension prevalence and its trend in Bangladesh: evidence from a systematic review and meta-analysis.孟加拉国的高血压患病率及其趋势：系统评价与荟萃分析的证据
Clin Hypertens. 2020 Jun 1;26:10. doi: 10.1186/s40885-020-00143-1. eCollection 2020.
8
Why does COVID-19 disproportionately affect older people?为什么新冠病毒对老年人的影响尤为严重？
Aging (Albany NY). 2020 May 29;12(10):9959-9981. doi: 10.18632/aging.103344.
9
Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis.预测严重 COVID-19 和入住重症监护病房的症状和合并症：系统评价和荟萃分析。
Int J Public Health. 2020 Jun;65(5):533-546. doi: 10.1007/s00038-020-01390-7. Epub 2020 May 25.
10
Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China.中国武汉 221 例 COVID-19 患者的临床特征和短期预后。
J Clin Virol. 2020 Jun;127:104364. doi: 10.1016/j.jcv.2020.104364. Epub 2020 Apr 9.