结构表征 DynU16，一种参与 dynemicin 生物合成的 START/Bet v1 样蛋白。
Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis.
机构信息
Department of BioSciences, Rice University, 6100 Main Street, Houston, TX 77005, USA.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
出版信息
Acta Crystallogr F Struct Biol Commun. 2021 Oct 1;77(Pt 10):328-333. doi: 10.1107/S2053230X21008943. Epub 2021 Sep 21.
The 1.5 Å resolution crystal structure of DynU16, a protein identified in the dynemicin-biosynthetic gene cluster, is reported. The structure adopts a di-domain helix-grip fold with a uniquely positioned open cavity connecting the domains. The elongated dimensions of the cavity appear to be compatible with the geometry of a linear polyene, suggesting the involvement of DynU16 in the upstream steps of dynemicin biosynthesis.
报道了一种在 dynemicin 生物合成基因簇中鉴定到的蛋白质 DynU16 的 1.5 Å 分辨率晶体结构。该结构采用双结构域螺旋夹折叠，具有独特定位的开放腔连接两个结构域。腔的细长尺寸似乎与线性多烯的几何形状兼容，表明 DynU16 参与了 dynemicin 生物合成的上游步骤。
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