纳米包裹达托霉素在耐甲氧西林金黄色葡萄球菌骨和关节感染模型中的疗效。
Efficacy of Nanoencapsulated Daptomycin in an Experimental Methicillin-Resistant Staphylococcus aureus Bone and Joint Infection Model.
机构信息
Université de Nantes, EA3826, IRS2 Nantes Biotech, Nantes, France.
Atlangram, IRS2 Nantes Biotech, Nantes, France.
出版信息
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0076821. doi: 10.1128/AAC.00768-21. Epub 2021 Oct 4.
Abstract
Staphylococcus aureus bone infections remain a therapeutic challenge, leading to long and expensive hospitalizations. Systemic antibiotic treatments are inconsistently effective, due to insufficient penetration into the infectious site. In an osteomyelitis model, the single local administration of nanoparticle-encapsulated daptomycin allows sterilization of the infectious sites after 4 and 14 days of treatment, while daily systemic daptomycin treatment for 4 days was not effective. These results demonstrate the great potential of this local antibiotic treatment.
摘要
金黄色葡萄球菌引起的骨感染仍然是一个治疗挑战，导致住院时间长且费用高。由于不能充分渗透到感染部位，全身抗生素治疗效果不一致。在骨髓炎模型中，纳米颗粒包裹的达托霉素单次局部给药，在治疗 4 天和 14 天后可使感染部位无菌，而每天全身给予达托霉素治疗 4 天则无效。这些结果表明这种局部抗生素治疗具有很大的潜力。
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