Hung Yuan-Pin, Chen Yu-Fon, Tsai Pei-Jane, Huang I-Hsiu, Ko Wen-Chien, Jan Jeng-Shiung
Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70007, Taiwan.
Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
Pharmaceutics. 2021 Nov 12;13(11):1913. doi: 10.3390/pharmaceutics13111913.
Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.
靶向细菌的纳米材料已广泛应用于细菌感染性疾病的诊断和治疗。这些纳米材料由于具有广谱抗菌能力和相对较低的毒性，作为抗菌剂显示出巨大潜力。最近，纳米材料提高了病原体的精确检测能力，提供了针对医院感染的治疗策略，并促进了诱导体液免疫和细胞免疫的抗原蛋白疫苗的递送。传统上受细菌定植阻碍的生物材料植入物，受益于它们防止细菌形成生物膜并扩散到相邻组织的能力。随着我们根据伤口修复的需求定制纳米材料、选择封装方法和材料、加入激活系统并添加免疫激活佐剂，伤口修复在功能和预防细菌感染方面都在不断改善。近年来，它们在抗菌应用方面取得了众多进展，但预计未来在传染病的诊断和治疗方面还会有进一步的扩展。
