[全合成消旋前列腺素F2α和15α-羟基-11-脱氧前列腺素E1对动力性肠梗阻家兔小肠运动的影响]
[Effect of totally synthetic racemic prostaglandins F2 alpha and 15 alpha-OH-11-deoxyprostaglandin E1 on small intestine motility in rabbits with dynamic ileus].
作者信息
Freĭmanis Ia F, Veveris M M, Gauens Ia K, Engelis A M
出版信息
Biull Eksp Biol Med. 1986 Jun;101(6):712-4.
PMID:3460643
Abstract
A comparative analysis of the effect of racemic PGF2 alpha--(+/-)PGF2 alpha, 15 alpha OH-II-deoxy-PGE1-(+/-)DPGE1, aceclidine, neostigmine methylsufate, galanthamini hydrobromidum, and pituitrine on the ileum motility was performed in rabbits with dynamic ileus induced by surgical trauma and peritonitis. In the model under study (+/-)PGF2 alpha was similar in its action to neostigmine methylsulfate and aceclidine, with (+/-)DPGE1 having a week effect.
摘要
在因手术创伤和腹膜炎诱发动态肠梗阻的家兔中，对消旋前列腺素F2α（±PGF2α）、15α-羟基-II-脱氧前列腺素E1（±DPGE1）、醋克利定、新斯的明甲硫酸盐、氢溴酸加兰他敏和垂体后叶素对回肠运动的影响进行了比较分析。在所研究的模型中，±PGF2α的作用与新斯的明甲硫酸盐和醋克利定相似，而±DPGE1的作用较弱。
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