Thor P, Konturek J W, Konturek S J, Anderson J H
Am J Physiol. 1985 Mar;248(3 Pt 1):G353-9. doi: 10.1152/ajpgi.1985.248.3.G353.
Intestinal myoelectric activity was measured in four conscious dogs with implanted monopolar electrodes after administration of prostaglandins (PG) and indomethacin (Indo), a potent inhibitor of PG biosynthesis. PGE2 and PGI2 given intravenously caused a dose-dependent decrease in the frequency of the migrating myoelectric complex (MMC) in fasted dogs and in postprandial spike activity in fed animals. In contrast, PGF2 alpha interrupted the MMC and caused a fedlike pattern in fasted dogs and did not affect the postprandial spike activity. Similar effects were observed after intra-arterial infusion of PGs. PGE2 and PGI2 infused into the superior mesenteric artery caused a dose-dependent inhibition of the fasted and postprandial pattern of myoelectric activity of the small bowel, whereas PGF2 alpha blocked the MMC and increased spike activity. Indo injected in a single intravenous dose caused a significant reduction in the MMC interval, and Indo infused intravenously in a constant dose induced fedlike motility pattern in fasted dogs but had little effect on the postprandial activity in these animals. This study demonstrates that exogenous PGs of E and I series administered intravenously or intra-arterially inhibit intestinal motility, whereas PGF2 alpha has opposite effects. The finding that Indo increases intestinal motility indicates that endogenous PGs are important in the physiological control of intestinal motility.
在四只植入单极电极的清醒犬中，在给予前列腺素（PG）和吲哚美辛（Indo，一种PG生物合成的强效抑制剂）后测量肠道肌电活动。静脉注射PGE2和PGI2会导致禁食犬的移行性肌电复合波（MMC）频率呈剂量依赖性降低，并使进食动物的餐后锋电位活动降低。相比之下，PGF2α会中断MMC，并在禁食犬中引起类似进食后的模式，且不影响餐后锋电位活动。动脉内输注PG后也观察到了类似的效果。将PGE2和PGI2注入肠系膜上动脉会导致小肠肌电活动的禁食和餐后模式受到剂量依赖性抑制，而PGF2α会阻断MMC并增加锋电位活动。单次静脉注射Indo会使MMC间隔显著缩短，以恒定剂量静脉输注Indo会在禁食犬中诱导出类似进食后的运动模式，但对这些动物的餐后活动影响很小。这项研究表明，静脉内或动脉内给予的外源性E系列和I系列PG会抑制肠道运动，而PGF2α具有相反的作用。Indo增加肠道运动的发现表明内源性PG在肠道运动的生理控制中很重要。
