Laboratoire de Physique Théorique et Modélisation, CY Cergy Paris Université, 95302, Cergy-Pontoise Cedex, France.
Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, Gif-sur-Yvette, France.
Sci Rep. 2021 Oct 4;11(1):19630. doi: 10.1038/s41598-021-99057-7.
How does cellular organization shape the spatio-temporal patterns of activity in the cortex while processing sensory information? After measuring the propagation of activity in the mouse primary somatosensory cortex (S1) in response to single whisker deflections with Voltage Sensitive Dye (VSD) imaging, we developed a two dimensional model of S1. We designed an inference method to reconstruct model parameters from VSD data, revealing that a spatially heterogeneous organization of synaptic strengths between pyramidal neurons in S1 is likely to be responsible for the heterogeneous spatio-temporal patterns of activity measured experimentally. The model shows that, for strong enough excitatory cortical interactions, whisker deflections generate a propagating wave in S1. Finally, we report that two consecutive stimuli activating different spatial locations in S1 generate two waves which collide sub-linearly, giving rise to a suppressive wave. In the inferred model, the suppressive wave is explained by a lower sensitivity to external perturbations of neural networks during activated states.
当处理感觉信息时，细胞组织如何塑造大脑皮层中活动的时空模式？在使用电压敏感染料 (VSD) 成像测量了对单个胡须偏转的小鼠初级体感皮层 (S1) 中的活动传播之后，我们开发了一个 S1 的二维模型。我们设计了一种从 VSD 数据中重建模型参数的推断方法，结果表明 S1 中锥体神经元之间的突触强度的空间异质性组织可能是导致实验测量的异质时空活动模式的原因。该模型表明，对于足够强的兴奋性皮层相互作用，胡须偏转在 S1 中产生传播波。最后，我们报告说，两个连续的刺激激活 S1 中不同的空间位置会产生两个亚线性碰撞的波，从而产生抑制波。在推断的模型中，抑制波是由在激活状态下对外部扰动的神经网络的敏感性降低解释的。
