Gonzales Daniel L, Khan Hammad F, Keri Hayagreev V S, Yadav Saumitra, Steward Christopher, Muller Lyle E, Pluta Scott R, Jayant Krishna
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Sci Adv. 2025 Jan 31;11(5):eadr4038. doi: 10.1126/sciadv.adr4038.
Linking sensory-evoked traveling waves to underlying circuit patterns is critical to understanding the neural basis of sensory perception. To form this link, we performed simultaneous electrophysiology and two-photon calcium imaging through transparent NeuroGrids and mapped touch-evoked traveling waves and underlying microcircuit dynamics. In awake mice, both passive and active whisker touch elicited traveling waves within and across barrels, with a fast early component followed by a late wave that lasted hundreds of milliseconds poststimulus. Notably, late waves were modulated by perceived value and predicted behavioral choice in a two-whisker discrimination task. We found that the late wave feature was (i) modulated by motor feedback, (ii) differentially engaged a sparse ensemble reactivation pattern across layer 2/3, which a balanced-state network model reconciled via feedback-induced inhibitory stabilization, and (iii) aligned to regenerative layer 5 apical dendritic Ca events. Our results reveal that translaminar spacetime patterns organized by cortical feedback support sparse touch-evoked traveling waves.
将感觉诱发的行波与潜在的神经回路模式联系起来对于理解感觉知觉的神经基础至关重要。为了建立这种联系，我们通过透明的神经网格同时进行了电生理学和双光子钙成像，并绘制了触觉诱发的行波和潜在的微回路动力学图。在清醒小鼠中，被动和主动触须触摸都会在桶内和桶间引发行波，早期有一个快速成分，随后是一个持续到刺激后数百毫秒的晚期波。值得注意的是，在双触须辨别任务中，晚期波受感知价值和预测行为选择的调节。我们发现晚期波特征：（i）受运动反馈调节；（ii）以不同方式参与了2/3层的稀疏整体再激活模式，平衡态网络模型通过反馈诱导的抑制性稳定作用对其进行了协调；（iii）与第5层顶树突钙再生事件对齐。我们的结果表明，由皮质反馈组织的跨层时空模式支持稀疏的触觉诱发行波。
