Division of Colorectal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Surgery, College of Medicine, Taif University, Taif, Saudi Arabia.
Nutr Clin Pract. 2022 Feb;37(1):153-166. doi: 10.1002/ncp.10754. Epub 2021 Oct 5.
Although body composition (BC) can be measured easily using bioelectrical impedance analysis (BIA), there are few studies of serial BC measurements in colorectal cancer (CRC). The purpose of the present study was to observe the serial change of BC in patients with CRC surgery from the initiation to the end of chemotherapy and to evaluate its clinical usefulness.
From July 2018 to November 2019, patients undergoing elective CRC surgery were enrolled. All clinical data were reviewed retrospectively. BIA data were collected prospectively at four time points (initial, discharge day, first chemotherapy, and 6 months later). BC was measured using a commercial BIA device.
A total of 160 patients were enrolled, and 110 (68.8%) patients were followed. Most BC measurements, such as weight, body mass index, skeletal muscle mass, skeletal muscle index, and fat mass index, were lowest at the first chemotherapy and rebounded after 6 months. Phase angle (PhA) and the ratio of extracellular water to total body water (ECW/TBW) were "V" shaped and inverted "V" shaped, respectively, and the peaks were on discharge days. This pattern of BC showed significant difference according to sarcopenia, old age (>70 years), and advanced stage (III or IV). The change of PhA and ECW/TBW sensitively pattern differences according to clinical aspect.
Using BIA, serial BC measurements were taken to establish a pattern based on clinical characteristics. PhA showed the most sensitive change according to the patient's clinical aspect.
尽管生物电阻抗分析（BIA）可轻松测量身体成分（BC），但有关结直肠癌（CRC）的 BC 连续测量的研究甚少。本研究的目的是观察 CRC 手术患者从化疗开始到结束时 BC 的连续变化，并评估其临床应用价值。
2018 年 7 月至 2019 年 11 月，纳入接受择期 CRC 手术的患者。回顾性审查所有临床数据。前瞻性地在四个时间点（初始、出院日、第一次化疗和 6 个月后）收集 BIA 数据。使用商业 BIA 设备测量 BC。
共纳入 160 例患者，110 例（68.8%）患者得到随访。大多数 BC 测量值，如体重、体重指数、骨骼肌量、骨骼肌指数和脂肪量指数，在第一次化疗时最低，并在 6 个月后反弹。相位角（PhA）和细胞外液与总体水的比值（ECW/TBW）呈“V”形和倒“V”形，峰值在出院日。这种 BC 模式根据肌肉减少症、高龄（>70 岁）和晚期（III 或 IV 期）存在显著差异。PhA 和 ECW/TBW 的变化根据临床特征呈现出明显的差异模式。
使用 BIA 连续测量 BC，根据临床特征建立模式。根据患者的临床特征，PhA 显示出最敏感的变化。
