Site and Enantioselective Aliphatic C-H Oxidation with Bioinspired Chiral Complexes.

Selective oxidation of aliphatic C-H bonds stands as an unsolved problem in organic synthesis, with the potential to offer novel paths for preparing molecules of biological interest. The quest for reagents that can perform this class of reactions finds oxygenases and their mechanisms of action as inspiration motifs. Among the numerous families of synthetic catalysts that have been explored, complexes with linear tetraazadentate ligands combining two aliphatic amines and two aromatic amine heterocycles display a structural versatility proven instrumental in the design of C-H oxidation reactions showing site and enantioselectivities, not accessible by conventional oxidants. This manuscript makes a review of recent advances in the field.