Division of Orthopaedics, Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Germany.
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Germany.
Facial Plast Surg Aesthet Med. 2024 Jul-Aug;26(4):481-487. doi: 10.1089/fpsam.2021.0063. Epub 2021 Oct 4.
Costal cartilage calcification (CCC) of the cartilage graft, commonly used in reconstruction of nasal/auricular deformities, can cause poor surgical outcome, but structural and quantitative analyses are lacking. To compare the prevalence, amount, and structural pattern of CCC from individuals by gender and age, as measured by digital contact radiography. This is a cross-sectional cadaveric study ( = 92) of the seventh rib cartilage. CCC prevalence/amount/structural pattern (central [c]/peripheral [p]/diffuse [d]) was analyzed within three age groups: I (<40 years), II (40-70 years), and III (>70 years). Qualitative and quantitative CCC analyses were set in relation to gender/structural pattern/age. CCC prevalence was gender independent (96.7%) and occurred in c/p/d: 12.4%/22.4%/65.2%. Structural CCC pattern differed between age groups (I: 80%; c/p/d: 26.7%/46.6%/6.7%; II: 100%; c/p/d: 18.0%/30.8%/51.2%; III: 100%; p/d: 2.6%/97.4%). The mean CCC amount (9.1%) was gender independent and showed a significant correlation with age ( = 0.001). The mean amount showed a significant difference between the structural pattern [d/p: 3.3 times higher ( = 0.006), d/c: 7.7 times higher ( < 0.001)] and age groups (I/II/III: 6.4/8.5%/10.9%), whereby the amount was higher in groups II (factor: 7.4; < 0.001) and III (factor: 16.5; < 0.001) compared with group I. These data show an age-/gender-independent high CCC prevalence in the general population (96.7%). CCC already occurred in young donors (<40 years) with a not negligible amount (6.4%). CCC increased with age and structural analysis showed a gender-/age-specific pattern, whereby males were prone to peripheral/females to central CCC. Diffuse CCC was observed as an age-independent sign for high CCC levels.
肋软骨钙化（CCC）是一种常用于重建鼻/耳畸形的软骨移植物，它会导致手术效果不佳，但目前缺乏结构和定量分析。本研究通过数字接触放射摄影，比较了不同性别和年龄个体的 CCC 发生率、数量和结构模式。
这是一项关于第七肋软骨的尸体研究（n=92），分析了三个年龄段（I<40 岁、II40-70 岁、III>70 岁）的 CCC 发生率/数量/结构模式（中央[C]/周围[P]/弥漫[D]）。CCC 的定性和定量分析与性别/结构模式/年龄有关。CCC 的发生率与性别无关（96.7%），其结构模式为 C/P/D：12.4%/22.4%/65.2%。CCC 结构模式在不同年龄组之间存在差异（I 组：80%；C/P/D：26.7%/46.6%/6.7%；II 组：100%；C/P/D：18.0%/30.8%/51.2%；III 组：100%；P/D：2.6%/97.4%）。CCC 数量（9.1%）与性别无关，与年龄呈显著相关（r=0.001）。CCC 数量在结构模式之间（D/P：高 3.3 倍；D/C：高 7.7 倍）和年龄组之间存在显著差异（I/II/III 组：6.4%/8.5%/10.9%），其中 II 组（倍数：7.4；P<0.001）和 III 组（倍数：16.5；P<0.001）的数量明显高于 I 组。这些数据表明，在一般人群中，CCC 存在一种与年龄/性别无关的高发生率（96.7%）。在年轻供体（<40 岁）中，CCC 已经发生，且数量不小（6.4%）。CCC 随年龄增加而增加，结构分析显示出一种性别/年龄特异性模式，即男性易发生周围型，女性易发生中央型。弥漫性 CCC 是一种与年龄无关的、CCC 水平高的标志。
