Mellberg J R, Castrovince L A, Rotsides I D
J Dent Res. 1986 Aug;65(8):1078-83. doi: 10.1177/00220345860650080701.
Artificial caries lesions were formed in thin sections of subsurface enamel sandwiched between protective sheets of plastic. Six lesions were placed into the buccal surfaces of lower partial dentures of seven subjects, covered with a stainless steel mesh to provide a plaque cover, and brushed with either a sodium monofluorophosphate or placebo dentifrice for four weeks, by means of a double-blind random cross-over design. Analysis of the lesions by quantitative microradiography revealed that significant remineralization (21%) occurred in the monofluorophosphate group and significant further demineralization (27%) in the placebo group. The difference between the active and placebo treatments was significant (p = 0.02), showing that the monofluorophosphate was effective not only in preventing lesion progression but also in promoting mineral deposition. The simultaneous presence of remineralized lesions and lesions with increased demineralization showed the non-uniformity of conditions within a mouth.
在夹于塑料保护片之间的牙釉质表层下薄片中形成人工龋损。将六个龋损置于七名受试者下颌局部义齿的颊面，用不锈钢网覆盖以形成菌斑覆盖，并通过双盲随机交叉设计，用单氟磷酸钠牙膏或安慰剂牙膏刷牙四周。通过定量显微放射照相术对龋损进行分析发现，单氟磷酸钠组发生了显著的再矿化（21%），而安慰剂组则出现了显著的进一步脱矿（27%）。活性治疗组与安慰剂治疗组之间的差异具有显著性（p = 0.02），表明单氟磷酸钠不仅在预防龋损进展方面有效，而且在促进矿物质沉积方面也有效。再矿化龋损和脱矿增加的龋损同时存在，表明口腔内情况存在不均一性。
