College of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, 530003, People's Republic of China.
School of Mechanical Engineering, Guangdong Songshan Polytechnic, Shaoguan, Guangdong, 512126, People's Republic of China.
Nanotechnology. 2021 Oct 22;33(2). doi: 10.1088/1361-6528/ac2d07.
It has been challenging to integrate various medical imaging modalities into an ultra-small nanoparticle with good biocompatibility to build highly efficient multimodal imaging nanoprobes. A new manganese and dysprosium codoped carbon quantum dots (Mn,Dy-CQDs) with a mean diameter of 1.77 nm was synthesized for fluorescence imaging,1/2-weighted magnetic resonance imaging (1/2-weighted MRI), and x-ray computed tomography (CT) imaging using a simple one-step hydrothermal approach. The obtained Mn,Dy-CQDs showed good water solubility, long-term stability, strong stable fluorescence property (fluorescence quantum yield of 31.62%), and excellent biocompatibility. The cell imaging verified that the Mn,Dy-CQDs have high efficiency of fluorescence imaging. The Mn,Dy-CQDs, on the other hand, had a superior x-ray absorption performance (47.344 HU l g), a higher longitudinal relaxivity ( = 7.47 mMs), a higher transverse relaxivity ( = 42.686 mMs).1/2-weighted MRI and CT imaging showed that Mn,Dy-CQDs can produce a strong contrast enhancement impact. To summarise, the Mn,Dy-CQDs may be used as a1/2-weighted MRI/CT/fluorescent quadri-modal imaging nanoprobe, indicating that they have a lot of uses in biomedical multimode imaging and clinics.
将各种医学成像模式整合到具有良好生物相容性的超小纳米颗粒中，以构建高效的多模式成像纳米探针一直具有挑战性。采用简单的一步水热法，合成了一种平均直径为 1.77nm 的新型锰和镝共掺杂碳量子点（Mn，Dy-CQDs），用于荧光成像、1/2 加权磁共振成像（1/2-weighted MRI）和 X 射线计算机断层扫描（CT）成像。所获得的 Mn，Dy-CQDs 表现出良好的水溶性、长期稳定性、强稳定荧光特性（荧光量子产率为 31.62%）和优异的生物相容性。细胞成像验证了 Mn，Dy-CQDs 具有高效的荧光成像效率。另一方面，Mn，Dy-CQDs 具有优异的 X 射线吸收性能（47.344HU l g）、更高的纵向弛豫率（r1=7.47mMs）和更高的横向弛豫率（r2=42.686mMs）。1/2-weighted MRI 和 CT 成像表明，Mn，Dy-CQDs 可以产生强烈的对比增强效果。总之，Mn，Dy-CQDs 可用作 1/2-weighted MRI/CT/荧光四模态成像纳米探针，表明它们在生物医学多模式成像和临床中具有广泛的用途。
