Molkenova Anara, Serik Lazzat, Ramazanova Alina, Zhumanova Kamila, Duisenbayeva Bakyt, Zhussupbekova Ainur, Zhussupbekov Kuanysh, Shvets Igor V, Kim Ki Su, Han Dong-Wook, Atabaev Timur Sh
Institute of Advanced Organic Materials, Pusan National University Busan 46241 Republic of Korea.
Department of Chemistry, Nazarbayev University Astana 010000 Kazakhstan
RSC Adv. 2023 May 16;13(22):14974-14979. doi: 10.1039/d3ra00958k. eCollection 2023 May 15.
Metal-doped carbon dots have attracted considerable attention in nanomedicine over the last decade owing to their high biocompatibility and great potential for bioimaging, photothermal therapy, and photodynamic therapy. In this study, we prepared, and for the first time, examined terbium-doped CDs (Tb-CDs) as a novel contrast agent for computed tomography. A detailed physicochemical analysis revealed that the prepared Tb-CDs have small sizes (∼2-3 nm), contain relatively high terbium concentration (∼13.3 wt%), and exhibit excellent aqueous colloidal stability. Furthermore, preliminary cell viability and CT measurements suggested that Tb-CDs exhibit negligible cytotoxicity toward L-929 cells and demonstrate high X-ray absorption performance (∼48.2 ± 3.9 HU L g). Based on these findings, the prepared Tb-CDs could serve as a promising contrast agent for efficient X-ray attenuation.
在过去十年中，金属掺杂碳点因其高生物相容性以及在生物成像、光热疗法和光动力疗法方面的巨大潜力，在纳米医学领域引起了广泛关注。在本研究中，我们首次制备并研究了铽掺杂碳点（Tb-CDs）作为计算机断层扫描的新型造影剂。详细的物理化学分析表明，所制备的Tb-CDs尺寸较小（约2-3纳米），铽浓度相对较高（约13.3 wt%），并表现出优异的水相胶体稳定性。此外，初步的细胞活力和CT测量表明，Tb-CDs对L-929细胞的细胞毒性可忽略不计，并具有高X射线吸收性能（约48.2±3.9 HU L g）。基于这些发现，所制备的Tb-CDs有望成为一种有效的X射线衰减造影剂。
