POU5F1 基因和 TCF19 基因之间反方向的exon 和 intron 共享-人类基因组中未被记录的现象。
Exon and intron sharing in opposite direction-an undocumented phenomenon in human genome-between Pou5f1 and Tcf19 genes.
机构信息
Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
出版信息
BMC Genomics. 2021 Oct 5;22(1):718. doi: 10.1186/s12864-021-08039-6.
BACKGROUND
Overlapping genes share same genomic regions in parallel (sense) or anti-parallel (anti-sense) orientations. These gene pairs seem to occur in all domains of life and are best known from viruses. However, the advantage and biological significance of overlapping genes is still unclear. Expressed sequence tags (ESTs) analysis enabled us to uncover an overlapping gene pair in the human genome.
RESULTS
By using in silico analysis of previous experimental documentations, we reveal a new form of overlapping genes in the human genome, in which two genes found on opposite strands (Pou5f1 and Tcf19), share two exons and one intron enclosed, at the same positions, between OCT4B3 and TCF19-D splice variants.
CONCLUSIONS
This new form of overlapping gene expands our previous perception of splicing events and may shed more light on the complexity of gene regulation in higher organisms. Additional such genes might be detected by ESTs analysis also of other organisms.
背景
重叠基因在平行（顺式）或反平行（反式）方向上共享相同的基因组区域。这些基因对似乎存在于所有生命领域，最著名的是病毒。然而，重叠基因的优势和生物学意义尚不清楚。表达序列标签（EST）分析使我们能够在人类基因组中发现一个重叠基因对。
结果
通过对先前实验文献的计算机分析，我们在人类基因组中揭示了一种新形式的重叠基因，其中两个位于相反链上的基因（Pou5f1 和 Tcf19），在 OCT4B3 和 TCF19-D 剪接变体之间的相同位置共享两个外显子和一个内含子。
结论
这种新形式的重叠基因扩展了我们以前对剪接事件的认识，并可能进一步揭示高等生物中基因调控的复杂性。通过对其他生物体的 EST 分析，也可能检测到更多这样的基因。
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