Abushamma Faris, Barqawi Abdulkarim, Al-Jabi Samah W, Akkawi Maha, Maree Mosab, Zyoud Sa'ed H
Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Department of Urology, An-Najah National University Hospital, Nablus, 44839, Palestine.
Cancer Manag Res. 2021 Sep 27;13:7479-7487. doi: 10.2147/CMAR.S324284. eCollection 2021.
Nephron-sparing surgery (NSS) for small renal masses (SRMs) is currently the standard of care to treat renal cell carcinoma (RCC). The concept of partial resection of RCC has mainly been developed to preserve kidney function. Therefore, we have performed this study to explore the research activity that has been undertaken since the early twenty-first century to investigate the advantages of NSS on preserving kidney function and preventing chronic kidney disease (CKD).
Based on the Scopus database, this bibliometric study was used to reveal publication patterns in the kidney function and NSS research field. The data were analysed with VOSviewer version 1.6.16 software, which was used to create a network visualisation map that included research hotspots in this area.
A total of 449 scientific publications focused on renal function in NSS between 2001 and 2020. One hundred and seventy (38%) of the total published articles originated from the USA. , , and were the top publications detailing research in this field. Half (50%) of the top 10 cited articles were published in the , with an average citation of around 200 per article. The three most encountered research themes were comparative studies between partial and radical nephrectomy in terms of kidney function and development of CKD, the impact of type and duration of ischemia during resection on glomerular filtration rate (GFR) decline, and the effect of different surgical approaches on intermediate and long-term kidney function.
NSS for SRMs and RCC and its impact on kidney function is a hot topic in the literature, and the amount of published data has consistently been rising since 2000. However, even though hundreds of documents have studied this topic from various perspectives, there is a compelling need to answer several questions such as the overall survival (OS) benefit of performing NSS in localised RCC and head-to-head comparison of robotic-assisted versus laparoscopic NSS in terms of warm ischemia time and long-term decline in GFR.
对于小肾肿块（SRM），保留肾单位手术（NSS）目前是治疗肾细胞癌（RCC）的标准治疗方法。RCC部分切除术的概念主要是为了保留肾功能而发展起来的。因此，我们开展了这项研究，以探索自21世纪初以来为研究NSS在保留肾功能和预防慢性肾脏病（CKD）方面的优势所进行的研究活动。
基于Scopus数据库，这项文献计量学研究用于揭示肾功能和NSS研究领域的发表模式。使用VOSviewer 1.6.16版本软件对数据进行分析，该软件用于创建一个网络可视化地图，其中包括该领域的研究热点。
2001年至2020年间，共有449篇关于NSS中肾功能的科学出版物。发表的文章总数中有170篇（38%）来自美国。 、 和 是详细阐述该领域研究的顶级出版物。被引用次数排名前十的文章中有一半（50%）发表在 上，每篇文章的平均引用次数约为200次。最常遇到的三个研究主题是部分肾切除术和根治性肾切除术在肾功能和CKD发展方面的比较研究、切除过程中缺血类型和持续时间对肾小球滤过率（GFR）下降的影响，以及不同手术方法对中长期肾功能的影响。
SRM和RCC的NSS及其对肾功能的影响是文献中的一个热门话题，自2000年以来发表的数据量一直在持续上升。然而，尽管已有数百篇文献从各种角度研究了这个话题，但仍迫切需要回答几个问题，例如在局限性RCC中进行NSS的总生存（OS）获益，以及机器人辅助NSS与腹腔镜NSS在热缺血时间和GFR长期下降方面的直接比较。
