Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus 44839, West Bank, Palestine.
Department of Gastroenterology, York Hospital, York Teaching Hospital NHS Foundation Trust, York YO31 8HE, United Kingdom.
World J Gastroenterol. 2021 Apr 7;27(13):1341-1353. doi: 10.3748/wjg.v27.i13.1341.
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut-brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut-brain axis.
To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this field.
The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000-2019. VOSviewer software was used for data visualization.
A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS ( = 0.951, < 0.001). The United States was the most prolific country with 449 (24%) publications, followed by the United Kingdom ( = 176, 9.4%), China ( = 154, 8.2%), and Italy ( = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters: (1) The gut-brain axis related to IBS; (2) Clinical trials related to IBS and the microbiome; (3) Drug-mediated manipulation of the gut microbiome; and (4) The role of the altered composition of intestinal microbiota in IBS prevention.
This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in IBS remains promising.
肠易激综合征（IBS）是一种常见的功能性胃肠道疾病。肠-脑轴失调在 IBS 的病理生理学中起着核心作用。越来越清楚的是，微生物组在肠-脑轴的发展和正常功能中起着关键作用。
促进确定可能与未来研究相关的特定重点领域。本研究对与 IBS 相关的微生物组文献进行了文献计量学分析，以了解该领域的发展情况。
我们的文献计量分析中使用的数据来自 Scopus 数据库。在 2000-2019 年期间，在标题或摘要中搜索与 IBS 和微生物组相关的术语。VOSviewer 软件用于数据可视化。
在全球范围内共检索到 13055 篇与 IBS 相关的文献。有 1872 篇关于 IBS 微生物组的科学出版物。所有领域与 IBS 相关的出版生产力与 IBS 微生物组相关的出版生产力之间存在强烈的正相关关系（ = 0.951， < 0.001）。美国是最具生产力的国家，有 449 篇（24%）出版物，其次是英国（ = 176，9.4%）、中国（ = 154，8.2%）和意大利（ = 151，8.1%）。所有与 IBS 微生物组相关的检索文献的 h 指数为 138。热门话题分为四个聚类：（1）与 IBS 相关的肠-脑轴；（2）与 IBS 和微生物组相关的临床试验；（3）药物介导的肠道微生物组操纵；（4）肠道微生物群落组成改变在 IBS 预防中的作用。
这是第一项评估和量化与 IBS 微生物组相关的全球研究生产力的研究。自 2013 年以来，关于 IBS 肠道微生物组的出版物数量不断增加。这一发现表明，针对 IBS 肠道微生物组的干预措施的未来前景仍然很有希望。
