Al Shudifat Abdulrahman, Al Suqi Hala, Soub Kutada, Al Nemrawi Leen, Abu Jaber Moa'tasem, Al Barbarawi Mohammad, Shewaikani Nour, El Adwan Yazan, Al Refaei Assem
Department of Neurosurgery, University of Jordan, Amman, Jordan.
School of Medicine, University of Jordan, Amman, Jordan.
Risk Manag Healthc Policy. 2021 Sep 27;14:4031-4035. doi: 10.2147/RMHP.S322546. eCollection 2021.
Our current study investigates the relationship between ABO blood groups and brain tumor incidence in the Jordanian pediatric population in a case-controlled manner.
This case-control study targeted pediatric primary brain tumor patients and tumor-free controls. Cases included patients younger than 18 when given a histologically confirmed diagnosis with a primary brain tumor, ascertained from two tertiary hospitals in Jordan. Controls were age- and gender-matched to cases and acquired from JUH pediatric clinics, with an exclusion for all patients with a personal history of tumors. Through using available records and calling guardians, our team obtained patients' and controls' blood groups.
Our case control included 81 (35.4%) pediatric primary brain tumor patients and age- and gender-matched tumor-free controls 148 (64.6%). When compared to O blood group, patients with A and B blood groups were not at higher risk of developing pediatric primary brain tumors (P=0.742, P=1.000, respectively). However, Chi-square analysis revealed a 2.79-fold higher risk for pediatric primary brain tumors in AB blood group patients (P=0.024). Gender-specific analysis revealed a 3.42-fold higher risk for pediatric brain tumors in AB blood group males when compared to O blood group males.
This work represents the first published study on the association between blood groups and pediatric brain tumors. With future research with larger samples and control of confounding factors, AB blood group may become a more established risk factor for pediatric brain tumors, aiding in screening.
我们当前的研究以病例对照的方式调查约旦儿科人群中ABO血型与脑肿瘤发病率之间的关系。
这项病例对照研究针对儿科原发性脑肿瘤患者和无肿瘤对照。病例包括在约旦的两家三级医院确诊为原发性脑肿瘤且年龄小于18岁的患者。对照与病例在年龄和性别上相匹配，从朱夫大学儿科诊所选取，排除所有有个人肿瘤病史的患者。通过查阅现有记录并致电监护人，我们的团队获取了患者和对照的血型。
我们的病例对照包括81例（35.4%）儿科原发性脑肿瘤患者以及年龄和性别匹配的148例无肿瘤对照（64.6%）。与O血型相比，A血型和B血型的患者患儿科原发性脑肿瘤的风险并不更高（分别为P = 0.742，P = 1.000）。然而，卡方分析显示AB血型患者患儿科原发性脑肿瘤的风险高2.79倍（P = 0.024）。按性别分析显示，与O血型男性相比，AB血型男性患儿科脑肿瘤的风险高3.42倍。
这项工作是关于血型与儿科脑肿瘤关联的首次发表研究。随着未来更大样本量的研究以及混杂因素的控制，AB血型可能成为儿科脑肿瘤更明确的风险因素，有助于筛查。
