Research Institute for Biomedical Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba, Japan.
Int Immunol. 2021 Nov 25;33(12):723-729. doi: 10.1093/intimm/dxab075.
The interleukin-17 (IL-17) family consists of six family members (IL-17A-IL-17F) and all the corresponding receptors have been identified recently. This family is mainly involved in the host defense mechanisms against bacteria, fungi and helminth infection by inducing cytokines and chemokines, recruiting neutrophils, inducing anti-microbial proteins and modifying T-helper cell differentiation. IL-17A and some other family cytokines are also involved in the development of psoriasis, psoriatic arthritis and ankylosing spondylitis by inducing inflammatory cytokines and chemokines, and antibodies against IL-17A as well as the receptor IL-17RA are being successfully used for the treatment of these diseases. Involvement in the development of inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and tumors has also been suggested in animal disease models. In this review, we will briefly review the mechanisms by which IL-17 cytokines are involved in the development of these diseases and discuss possible treatment of inflammatory diseases by targeting IL-17 family members.
白细胞介素-17（IL-17）家族由六个家族成员（IL-17A-IL-17F）组成，最近所有相应的受体都已被鉴定。该家族主要通过诱导细胞因子和趋化因子、募集中性粒细胞、诱导抗菌蛋白和调节辅助性 T 细胞分化来参与宿主防御机制，以抵抗细菌、真菌和寄生虫感染。白细胞介素-17A 和其他一些家族细胞因子也通过诱导炎症细胞因子和趋化因子参与银屑病、银屑病关节炎和强直性脊柱炎的发展，针对白细胞介素-17A 以及受体白细胞介素-17RA 的抗体正在成功用于这些疾病的治疗。在动物疾病模型中也提示其参与了炎症性肠病、多发性硬化症、类风湿关节炎和肿瘤的发展。在这篇综述中，我们将简要回顾白细胞介素-17 细胞因子在这些疾病发展中的作用机制，并讨论通过靶向白细胞介素-17 家族成员治疗炎症性疾病的可能性。
